Local ice cryotherapy decreases synovial interleukin 6, interleukin 1β, vascular endothelial growth factor, prostaglandin-E2, and nuclear factor kappa B p65 in human knee arthritis: a controlled study

Arthritis Research & Therapy
Xavier GuillotDaniel Wendling

Abstract

The aim of this study was to assess the anti-inflammatory effects of local cryotherapy in human non-septic knee arthritis. In the phase I of the study, patients were randomized to receive either ice (30 min; N = 16) or cold CO2 (2 min; N = 16) applied twice during 1 day at an 8-h interval on the arthritic knee. In phase II, 16 other ice-treated arthritic knees according to the same protocol were compared to the contralateral non-treated arthritic knees (N = 16). The synovial fluid was analyzed just before the first cold application, then 24 h later. IL-6, IL-1β, TNF-α, IL-17A, VEGF, NF-kB-p65 protein, and PG-E2 levels were measured in the synovial fluid and compared before/after the two cold applications. Forty-seven patients were included (17 gouts, 11 calcium pyrophosphate deposition diseases, 13 rheumatoid arthritides, 6 spondyloarthritides). Local ice cryotherapy significantly reduced the IL-6, IL-1β, VEGF, NF-kB-p65, and PG-E2 synovial levels, especially in the microcrystal-induced arthritis subgroup, while only phosphorylated NF-kB-p65 significantly decreased in rheumatoid arthritis and spondyloarthritis patients. Cold CO2 only reduced the synovial VEGF levels. In the phase II of the study, the synovial PG-E2 was signific...Continue Reading

Associated Clinical Trials

References

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Citations

Nov 12, 2020·Scandinavian Journal of Medicine & Science in Sports·Daniela Pacheco Dos Santos HaupenthalPaulo Cesar Lock Silveira
May 19, 2020·Joint, Bone, Spine : Revue Du Rhumatisme·Augustin LatourteThomas Bardin
Apr 28, 2021·Therapeutic Hypothermia and Temperature Management·Alana Ludemila de Freitas TavaresGladson Ricardo Flor Bertolini
Jun 3, 2021·International Journal of Environmental Research and Public Health·Aleksandra RadeckaAnna Lubkowska

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Methods Mentioned

BETA
flow
ELISA

Clinical Trials Mentioned

NCT03850392

Software Mentioned

Graphpad®
rmeta®
meta®

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