Local immune response depends on p16INK4a status of primary tumor in vulvar squamous cell carcinoma

Oncotarget
Jacek J SznurkowskiWojciech Biernat

Abstract

The p16Ink4a is not a surrogate marker for high-risk human papilloma virus (HPV) genotypes but indicates better prognosis in vulvar squamous cell carcinoma patients. Our recent study confirmed substantial mismatch between p16Ink4a and high-risk HPV-status as well as revealed that p16Ink4a-overexpression itself is an independent prognostic factor for vulvar cancer. To determine significance of the tumor infiltrating immune cells and p16Ink4a-status for better outcome of patients with vulvar cancer. Intraepithelial tumor infiltrating lymphocytes: CD8+, CD4+, FOXP3+, CD56+, tumor associated macrophages: CD68+, and GZB+ cells were calculated in 85 vulvar squamous cell carcinomas with previously defined p16Ink4a and high-risk HPV-status. Number of intraepithelial CD8+, CD4+, FOXP3+, CD56+, CD68+ and GZB+ cells were compared between tumors with different p16INK4a status and overlapping high-risk HPV-status separately. Survival analyses included the Kaplan-Meier method, log-rank test and Cox proportional hazards model. p16Ink4a-negative tumors were more infiltrated by intraepithelial CD8+, CD4+ and GZB+ cells than p16Ink4a-positive tumors (p=0.032, p=0.016 and p=0.007 respectively). High-risk HPV-status did not correlate with the infi...Continue Reading

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Citations

Apr 27, 2020·Journal of Cancer Research and Clinical Oncology· Giulia MantovaniGiorgia Garganese
Jun 27, 2018·Cancer Immunology, Immunotherapy : CII·Georgia KarpathiouMichel Peoc'h
Jul 6, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jo MorrisonChristina Fotopoulou
Dec 31, 2020·International Journal of Molecular Sciences·Fulvio BorellaLeonardo Micheletti

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Methods Mentioned

BETA
dissection
genotyping

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Statistica
Multiscan

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