Local immune response to Escherichia coli pili in experimental pyelonephritis.

Infection and Immunity
J W SmithR M Swenson

Abstract

The local immune response to pili of Escherichia coli O6:K13:H1 was determined in experimental hematogenous pyelonephritis in rabbits. Pili purified from sheared cells by ammonium sulfate precipitation were found to be pure by electron microscopy and negative for lipopolysaccharide by limulus lysate assay. Antipilus antibody was detected in serum and newly synthesized protein from infected animals with enzyme-linked immunosorbent assay. Serum and local (intrarenal) antibodies were of the immunoglobulin G class, were detectable by day 20 of infection, and persisted though 250 days of infection. These data suggest that pili are present on the organism at the site of infection, since they induce the local synthesis of antipilus antibody in experimental pyelonephritis.

References

Nov 1, 1977·The Journal of Experimental Medicine·I E Salit, E C Gotschlich
Apr 1, 1977·The Journal of Infectious Diseases·J W SmithB Kaijser
Aug 1, 1976·The Journal of Clinical Investigation·J W Smith, B Kaijser
Nov 1, 1969·The Journal of Clinical Investigation·J D LehmannJ P Sanford
Nov 1, 1973·The Journal of Clinical Investigation·T M BuchananE C Gotschlich
Feb 1, 1980·Infection and Immunity·I OrskovA Birch-Andersen

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