Local immune responses of the Chinese water buffalo, Bubalus bubalis, against Schistosoma japonicum larvae: crucial insights for vaccine design

PLoS Neglected Tropical Diseases
Hamish E G McWilliamE N T Meeusen

Abstract

Asian schistosomiasis is a zoonotic parasitic disease infecting up to a million people and threatening tens of millions more. Control of this disease is hindered by the animal reservoirs of the parasite, in particular the water buffalo (Bubalus bubalis), which is responsible for significant levels of human transmission. A transmission-blocking vaccine administered to buffaloes is a realistic option which would aid in the control of schistosomiasis. This will however require a better understanding of the immunobiology of schistosomiasis in naturally exposed buffaloes, particularly the immune response to migrating schistosome larvae, which are the likely targets of an anti-schistosome vaccine. To address this need we investigated the immune response at the major sites of larval migration, the skin and the lungs, in previously exposed and re-challenged water buffaloes. In the skin, a strong allergic-type inflammatory response occurred, characterised by leukocyte and eosinophil infiltration including the formation of granulocytic abscesses. Additionally at the local skin site, interleukin-5 transcript levels were elevated, while interleukin-10 levels decreased. In the skin-draining lymph node (LN) a predominant type-2 profile was s...Continue Reading

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Citations

Jun 27, 2014·Parasites & Vectors·Hamish E G McWilliamE N T Meeusen
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Methods Mentioned

BETA
RNA
ELISA

Related Concepts

Syncerus
Tadpole
Lung
Lymph Nodes
Schistosoma japonicum
Schistosomiasis Japonica
Skin
Vaccines
Buffaloes
Larva

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