Local infiltration anesthesia versus epidural analgesia for postoperative pain control in total knee arthroplasty: a systematic review and meta-analysis

Journal of Orthopaedic Surgery and Research
Chen LiYang Qu

Abstract

We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of local infiltration anesthesia (LIA) versus epidural analgesia (EPA) for postoperative pain control in total knee arthroplasty (TKA). In December 2017, a systematic computer-based search was conducted in Pubmed, EMBASE, Web of Science, and Cochrane Database of Systematic Reviews. RCTs of patients prepared for spine surgery that compared LIA versus EPA for postoperative pain control in TKA were retrieved. The primary endpoint was the VAS score with rest or mobilization at 12, 24 and 48, and 72 h. The secondary outcomes were the range of motion, the length of stay, and the occurrence of infection and nausea. After testing for publication bias and heterogeneity between studies, data were aggregated for random-effects models when necessary. Seven clinical studies with 251 patients (LIA = 124, EPA = 127) were included in the meta-analysis. There was no significant difference between LIA and EPA group in terms of the VAS score with rest at 12 and 24 h. LIA was associated with a reduction of the VAS score with rest at 48 and 72 h than EPA (P < 0.05). There was no significant difference between the LIA group a...Continue Reading

References

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Citations

Sep 15, 2019·Operative Orthopädie und Traumatologie·Wolf PetersenMartin Häner
Dec 12, 2018·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Koji AsoMasahiko Ikeuchi
Dec 13, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Rune D BechSøren Overgaard
Oct 31, 2019·Orthopaedic Surgery·Jing-Wen LiLiang-Kun Xiao
Jun 14, 2021·Brazilian Journal of Anesthesiology·Javier Ripollés-MelchorUNKNOWN POWER2 Study Investigators Group for the Spanish Perioperative Audit and Research Network (RedGERM-SPARN)

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Methods Mentioned

BETA
total hip arthroplasty

Software Mentioned

GetData Graph Digitizer
Stata
Endnote X7

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