Local infusion of norepinephrine reduces blood losses and need of transfusion in total knee arthroplasty

International Orthopaedics
G GaspariniC Fabbriciani

Abstract

Blood loss after total knee arthroplasty (TKA) is often associated with cardiovascular complications and a high transfusion rate of allogenic blood. In our study we focused our attention on developing a new intra-surgical procedure that appears safe, easy to perform and effective in the reduction of bleeding in TKA. We evaluated 84 patients who underwent TKA and met our inclusion criteria; they were assigned to two groups: 55 controls in which a saline solution was used to wash the surgical field before tourniquet release, and a second group of 29 patients, in which a saline solution containing a low dose of norepinephrine was locally applied before tourniquet release. The local administration of a low dose of norepinephrine has induced a significant reduction of perioperative blood loss and blood transfusion requirements; in addition, this method was characterised by the absence of complications or adverse effects. In conclusion, our data suggest that intraoperative local administration of a low dose of norepinephrine could represent an effective and safe method of reducing blood loss and preventing blood transfusions in patients with TKA.

References

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Citations

Sep 21, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Hideyuki SasanumaYuichi Hoshino
Nov 16, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Tomislav MadarevicLana Ruzic
Sep 13, 2011·Archives of Orthopaedic and Trauma Surgery·Alfred O OgbemudiaLoius West-Osemwengie
Oct 18, 2011·International Urology and Nephrology·Alejandro Lira-DaleIvan Delgado-Enciso
Mar 28, 2013·Indian Journal of Orthopaedics·Paras Kumar MohanlalSr Samsani
Apr 11, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Alfredo Schiavone PanniChiara Del Regno
Apr 9, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Marcello De FineCesare Faldini
Jan 24, 2014·Acta ortopedica brasileira·Camilo Partezani HelitoGilberto Luis Camanho
May 31, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Yuangang WuBin Shen
Nov 1, 2018·Revista Brasileira De Ortopedia·Mariana Diana Chaves de AlmeidaNaasson Cavanellas
May 10, 2011·The Open Orthopaedics Journal·Miguel Ortega-AndreuEnrique Gómez-Barrena
Dec 12, 2012·Anesthesia and Analgesia·Lawrence Tim Goodnough, Aryeh Shander
Dec 1, 2010·Clinical Orthopaedics and Related Research·Christophe LévigneGilles Walch
Nov 6, 2013·The Bone & Joint Journal·K R ReinhardtE P Su
Jul 10, 2018·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Vasileios SoranoglouThomas P Sculco

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