Abstract
Crossovers (COs) are formed during meiosis by the repair of programmed DNA double-strand breaks (DSBs) and are required for the proper segregation of chromosomes. More DSBs are made than COs, and the remaining DSBs are repaired as noncrossovers (NCOs). The distribution of recombination events along a chromosome occurs in a stereotyped pattern that is shaped by CO-promoting and CO-suppressing forces, collectively referred to as crossover patterning mechanisms. Chromosome inversions are structural aberrations that, when heterozygous, disrupt the recombination landscape by suppressing crossing over. In Drosophila species, the local suppression of COs by heterozygous inversions triggers an increase in crossing over on freely recombining chromosomes termed the interchromosomal (IC) effect [1, 2]. The molecular mechanism(s) by which heterozygous inversions suppress COs, whether noncrossover gene conversions (NCOGCs) are similarly affected, and what mediates the increase in COs in the rest of the genome remain open questions. By sequencing whole genomes of individual offspring from mothers containing heterozygous inversions, we show that, although COs are suppressed by inversions, NCOGCs occur throughout inversions at higher than wild...Continue Reading
Citations
Nov 8, 2018·Molecular Ecology·Zachary L FullerStephen W Schaeffer
Nov 6, 2018·Molecular Ecology·Katharine L Korunes, Mohamed A F Noor
Sep 20, 2018·Molecular Ecology·Martin Kapun, Thomas Flatt
Sep 19, 2019·Genetics·Beth A RowanDetlef Weigel
Oct 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Katherine Kretovich BillmyreR Scott Hawley
Aug 23, 2019·The Plant Journal : for Cell and Molecular Biology·Pasquale TermolinoClara Conicella
Nov 2, 2018·PLoS Genetics·Qianyan LiJoAnne Engebrecht
Jun 21, 2020·Genes·Fabilene Gomes PaimAnna Rita Rossi
May 31, 2020·Nature Reviews. Genetics·Joshua V Peñalba, Jochen B W Wolf
Jul 14, 2020·The New Phytologist·Steven DreissigKlaus Pillen
Jan 22, 2020·Nature Ecology & Evolution·Zheng YanLaurent Keller
Nov 8, 2019·PLoS Genetics·Danny E MillerR Scott Hawley
Jul 23, 2020·Molecular Biology and Evolution·Deborah CharlesworthLengxob Yong
Nov 8, 2020·Genetics·Danny E Miller
Apr 11, 2020·Current Biology : CB·Kieran SamukMohamed A F Noor
Jan 7, 2021·Genome Biology·Jiantao GuanHua Xie
Nov 14, 2020·Genes & Development·Xiaojing MuScott Keeney
Mar 5, 2021·PLoS Genetics·Emma L BerdanClaudia Bank
May 7, 2021·Genetics·Danny E Miller
Nov 1, 2019·Genetics·Beth A RowanDetlef Weigel
Apr 13, 2021·Evolution; International Journal of Organic Evolution·Marina RafajlovićRui Faria
May 7, 2021·Molecular Ecology·Emma L BerdanInês Fragata
May 27, 2021·Journal of Cell Science·Lexy von Diezmann, Ofer Rog
May 29, 2021·Nature Plants·Zhesi HeIan Bancroft
Mar 20, 2021·Genome Biology and Evolution·Juanita Gutiérrez-ValenciaTanja Slotte
Jun 11, 2021·BMC Medical Genomics·Trenell J MosleyJennifer G Mulle
May 28, 2021·Evolution; International Journal of Organic Evolution·Katharine L KorunesMohamed A F Noor
Aug 7, 2021·Genes·Linyi ZhangZachariah Gompert
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Nila M PazhayamJeff Sekelsky
Aug 25, 2021·Genome Research·Andrew J TockIan R Henderson