Local Inversion Heterozygosity Alters Recombination throughout the Genome

Current Biology : CB
K Nicole CrownR Scott Hawley

Abstract

Crossovers (COs) are formed during meiosis by the repair of programmed DNA double-strand breaks (DSBs) and are required for the proper segregation of chromosomes. More DSBs are made than COs, and the remaining DSBs are repaired as noncrossovers (NCOs). The distribution of recombination events along a chromosome occurs in a stereotyped pattern that is shaped by CO-promoting and CO-suppressing forces, collectively referred to as crossover patterning mechanisms. Chromosome inversions are structural aberrations that, when heterozygous, disrupt the recombination landscape by suppressing crossing over. In Drosophila species, the local suppression of COs by heterozygous inversions triggers an increase in crossing over on freely recombining chromosomes termed the interchromosomal (IC) effect [1, 2]. The molecular mechanism(s) by which heterozygous inversions suppress COs, whether noncrossover gene conversions (NCOGCs) are similarly affected, and what mediates the increase in COs in the rest of the genome remain open questions. By sequencing whole genomes of individual offspring from mothers containing heterozygous inversions, we show that, although COs are suppressed by inversions, NCOGCs occur throughout inversions at higher than wild...Continue Reading

Citations

Nov 6, 2018·Molecular Ecology·Katharine L Korunes, Mohamed A F Noor
Oct 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Katherine Kretovich BillmyreR Scott Hawley
Aug 23, 2019·The Plant Journal : for Cell and Molecular Biology·Pasquale TermolinoClara Conicella
May 31, 2020·Nature Reviews. Genetics·Joshua V Peñalba, Jochen B W Wolf
Jan 22, 2020·Nature Ecology & Evolution·Zheng YanLaurent Keller
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Apr 13, 2021·Evolution; International Journal of Organic Evolution·Marina RafajlovićRui Faria
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