Local irradiation alters bone morphology and increases bone fragility in a mouse model

Journal of Biomechanics
James D WernleKenneth A Mann

Abstract

Insufficiency fracture following radiation therapy (RTx) is a challenging clinical problem and typical bone mass measures fail to predict these fractures. The goals of this research were to develop a mouse model that results in reduced bone strength following focal irradiation, quantify morphological and strength changes occurring over time, and determine if a positive correlation between bone morphology and strength is retained after irradiation. Right hind limbs of 13 week-old female Balb/c mice were irradiated (5 or 20 Gy) using a therapeutic X-ray unit. Left limbs served as control. Animals were euthanized at 2, 6, 12, or 26 weeks. Axial compression tests of the distal femur were used to quantify whole bone strength. Specimen-specific, non-linear finite element (FE) analyses of the mechanical tests were performed using voxel-based meshes with two different material failure models: a linear bone density-strength relationship and a non-linear 'embrittled' relationship. Radiation resulted in a dose dependent increase in cortical bone density and marked loss of trabecular bone, measured using micro-CT. An early (2 week) increase in bone volume was associated with an increase in bone strength following irradiation; at 12 weeks t...Continue Reading

References

Nov 1, 1979·Oral Surgery, Oral Medicine, and Oral Pathology·M D RohrerJ V Fayos
Dec 1, 1975·Radiology·W J HowlandR G Johnson
May 1, 1996·International Journal of Radiation Oncology, Biology, Physics·A Konski, M Sowers
May 28, 2003·Radiation and Environmental Biophysics·Masahiko Sawajiri, Jun'etsu Mizoe
Aug 7, 2003·American Journal of Clinical Oncology·Bryan MarguliesTimothy Damron
Oct 31, 2003·International Journal of Clinical Oncology·Yasuhiro InoueMasato Kusunoki
Dec 16, 2003·Journal of Biomechanics·Harun H BayraktarTony M Keaveny
May 26, 2004·Archives of Internal Medicine·Ethel S SirisMarc L Berger
Aug 13, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Pawel SzulcPierre D Delmas
Jun 3, 2006·Journal of Applied Physiology·S A HamiltonT A Bateman
Aug 3, 2006·International Journal of Radiation Biology·Peter NiehoffYahya Acil
May 23, 2008·Radiation Research·Eric R BandstraTed A Bateman
Sep 4, 2008·Radiation Research·Jeffrey S WilleyTed A Bateman
Sep 23, 2008·AJR. American Journal of Roentgenology·Jong Won KwonBong Keun Choe
Nov 26, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·James F Griffith, Harry K Genant

❮ Previous
Next ❯

Citations

Jun 11, 2014·Lasers in Medical Science·Jonas D BatistaRogério M Pagnoncelli
Mar 1, 2011·Clinical Reviews in Bone and Mineral Metabolism·Jeffrey S WilleyTed A Bateman
Sep 25, 2015·Clinical Orthopaedics and Related Research·Polina OslerJoseph H Schwab
Feb 6, 2016·Calcified Tissue International·Megan E OestTimothy A Damron
Aug 22, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B J EdwardsT A Guise
Sep 20, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Andrew D MercurioMatthew J Allen
Nov 20, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Megan E OestTimothy A Damron
Jun 3, 2014·International Journal of Radiation Biology·Ian D HutchinsonJeffrey S Willey
May 9, 2015·Calcified Tissue International·Guillaume MichelFlorent Espitalier
Apr 8, 2014·Radiation Research·Megan E Oest, Timothy A Damron
Jun 19, 2013·Radiation Research·Lihini KeenawinnaTimothy A Damron
Oct 23, 2012·Free Radical Biology & Medicine·Tapasi RanaSwati Biswas
Sep 3, 2016·Microscopy Research and Technique·Flaviana Soares RochaPaula Dechichi
Sep 23, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christopher M BartlowTimothy A Damron
Oct 21, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Abhishek ChandraLing Qin
May 12, 2017·Brazilian Dental Journal·Mayra Cristina YamasakiDeborah Queiroz Freitas
May 18, 2012·Journal of Dental Research·J XuS L Wang
Feb 17, 2018·Connective Tissue Research·Jian ZhangGuangming Zhou
Apr 22, 2015·Clinical Orthopaedics and Related Research·Ishaq IbrahimSteven Gitelis
Nov 18, 2015·Molecular Medicine Reports·Yu WangJunxiang Chen
Oct 23, 2019·International Journal of Molecular Medicine·Jianglong ZhaiGuoying Zhu
May 26, 2017·Journal of Radiation Research·Jian ZhangGuangming Zhou
Sep 14, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Megan E OestTimothy A Damron
Dec 14, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jeffrey A Meganck, Bob Liu
Dec 14, 2018·Maxillofacial Plastic and Reconstructive Surgery·Hong-Moon JungTae-Geon Kwon
Oct 20, 2020·Current Osteoporosis Reports·Cari M WhyneMichael Hardisty
Feb 1, 2021·Calcified Tissue International·Patricia K ThomasAnthony G Lau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.