PMID: 9378533Nov 5, 1997Paper

Local low-dose interleukin-2 induces systemic immunity when combined with radiotherapy of cancer. A pre-clinical study

International Journal of Cancer. Journal International Du Cancer
Linda Ann EverseJ J Battermann

Abstract

Tumor recurrence and outgrowth of metastases limit the therapeutical effect of radiotherapy. We have tested whether these problems can be overcome by supplementing radiotherapy with locoregional interleukin-2 (IL-2) treatment. The SL2 lymphoma and the M8013 mammary carcinoma were used. Mice bearing a 10-day-old s.c. tumor were locally irradiated and were treated daily with IL-2 peritumorally for 5 or 10 days. Low-dose IL-2 therapy improved local response (LR) and increased disease-free survival (DFS) in both tumor models following either single-dose irradiation or fractionated irradiation. For example, 93% of SL2-bearing mice treated with single-dose irradiation and 10 days of IL-2 experienced long-term DFS, compared with 17% for irradiation alone (p < 0.0001). Additionally, treatment of one tumor with irradiation +IL-2 led to anti-tumor effects in a second, untreated tumor in 80% of SL2-bearing mice. LR was increased to 100% and DFS to 70% when the second, non-irradiated tumor was also treated with peritumoral IL-2. We conclude that supplementing local radiotherapy with low doses of IL-2 results in increased local tumor control and regression of distant, non-irradiated tumors. This type of radioimmunotherapy is a promising new...Continue Reading

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Citations

Feb 8, 2008·Cancer Immunology, Immunotherapy : CII·Willem Den OtterJan Willem Koten
Sep 10, 2013·Seminars in Radiation Oncology·Byron Burnette, Ralph R Weichselbaum
Dec 1, 2006·Veterinary and Comparative Oncology·D H Thamm
Jun 21, 2005·Veterinary Immunology and Immunopathology·Rachel J E StewartWillem Den Otter
Nov 17, 2020·Oncoimmunology·Ben G L VannesteDirk De Ruysscher
Jul 27, 2021·Frontiers in Oncology·Karl-Göran Tranberg
Sep 24, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raquibul HannanJames Brugarolas

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