PMID: 8603798Jan 1, 1996Paper

Local lymph node activation in rats after dermal application of the sensitizers 2,4-dinitrochlorobenzene and trimellitic anhydride

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Josje H E ArtsC Frieke Kuper

Abstract

Five rat strains were compared for their performance in the local lymph node assay (LLNA), a promising test system for the identification of the skin-sensitizing potential of chemicals in the mouse. The contract sensitizer 2,4-dinitrochlorobenzene (DNCB) and the contact and respiratory sensitizer trimellitic anhydride (TMA) were used as model chemicals and responses in rats were compared with those in BALB/c mice. The chemicals were applied to the dorsum of both ears, once daily for three consecutive days; 2 days (mice) or 3 days (rats) thereafter, proliferating cells were labelled by i.p. injection of BrdU 2 hr before the animals were killed. Systemic effects were subsequently assessed by determination of spleen, liver and kidney weights, skin effects by determination of swelling and inflammatory cell infiltration of the ears, and immune effects by determination of weight and proliferative activity of the local lymph nodes (LLN). Following application (x 3) of DNCB or TMA, minor systemic effects were observed, as indicated by slightly elevated spleen and liver weights in a few rat strains and the mice. Skin effects, consisting of increased ear thickness and presence of mononuclear inflammatory cell infiltrates, were observed i...Continue Reading

References

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Citations

Mar 6, 2012·Immunologic Research·A PopovM Kataranovski
Nov 7, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R J DearmanI Kimber
Mar 9, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T HariyaH Ichikawa
Oct 3, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L M KnippelsG F Houben
Mar 18, 2000·Toxicology Letters·C F KuperN Bloksma
Jun 1, 2003·Environmental Toxicology and Pharmacology·Jong Kwon LeeHye Young Oh
Feb 13, 2003·Contact Dermatitis·Ian KimberG F Gerberick
Jan 16, 2016·Anatomy & Cell Biology·Ok Hee Chai, Chang Ho Song
Nov 21, 2007·Toxicology and Applied Pharmacology·Darrell R BoverhofMichael R Woolhiser
Mar 1, 2010·Toxicological Research·Bae-Hwan Kim
Oct 8, 1999·Journal of Applied Toxicology : JAT·R J DearmanI Kimber
Dec 13, 2006·Methods : a Companion to Methods in Enzymology·Josje H E Arts, C Frieke Kuper
May 12, 2006·Critical Reviews in Toxicology·Josje H E ArtsCees de Heer
Aug 30, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Du Hyeon HwangEuikyung Kim
Sep 29, 2021·Immunopharmacology and Immunotoxicology·Deepa S MandlikSnehal S Patel

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