PMID: 1209000Jan 1, 1975Paper

Local myocardial blood-flow measured by the use of a needle-type Pt-H2 electrode

Recent Advances in Studies on Cardiac Structure and Metabolism
T Koyama

Abstract

In order to measure local myocardial blood flow respectively, a needle-type recessed Pt electrode sealed in a thin injection needle was constructed. By means of this electrode, the myocardial blood flow in the inner and outer portions of the anterior wall of the exposed left ventricle of anesthesized dogs was studied. Under conditions, the blood flow in the inner portion (112.4 ml/100 ml/min) exceeded that in the outer portion (98.7 ml/100 ml/min). But the blood flow distribution expressed in terms of the blood flow ratio in both portions was readily varied by several pharmacological treatments, starvation, or prolongation of the experiment. Combining these observations with the results obtained in the decrease of the O2 current in the coronary occlusion test, the following possibilities seemed probable: 1) The myocardial blood flow under normal conditions was so distributed that the inner layer could be supplied with an increased blood flow and more oxygen. 2) Such a balance between the local blood flow and O2 demand can often be disturbed under various conditions, as was seen in the case of isoproterinol infusion in the present study.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.