PMID: 7334360Jan 1, 1981Paper

Local production of mumps IgG and IgM antibodies in the cerebrospinal fluid of meningitis patients

Journal of Medical Virology
P UkkonenK Penttinen

Abstract

Immunoglobulin G (IgG) and M (IgM) antibodies against mumps virus were measured by an enzyme-linked immunosorbent assay (ELISA) in the serum and cerebrospinal fluid (CSF) specimens of patients with mumps meningitis. The CSF IgG antibodies correlated well with the respective antibody titers in serum. On the contrary, in only about half of the patients a moderate correlation was found between the CSF and serum IgM antibody titers, while the other patients did not have detectable mumps IgM antibodies in CSF irrespective of intermediate to high titers in serum. Two different immunologic mechanisms may be involved in these two groups which, however, did not show any clinical differences. The lack of IgM antibodies in the CSF of many patients diminished the value of CSF in the laboratory diagnosis of mumps meningitis compared to use of serum specimens. Intrathecal synthesis of mumps IgG antibodies was demonstrated in 83% of the patients, and of IgM antibodies in at least 67% of those patients with detectable IgM antibodies in CSF. The ratio between mumps IgG and IgM antibodies was higher in CSF than in serum, suggesting that the synthesis of IgG antibodies in central nervous system was more efficient than that of IgM antibodies.

References

Jul 28, 1978·JAMA : the Journal of the American Medical Association·D P LevineA M Lerner
Jan 1, 1978·Acta Obstetricia Et Gynecologica Scandinavica·E Sadovsky, M Perlman
Jan 1, 1979·Journal of Medical Virology·H HofmannC Kunz
Jan 1, 1978·Scandinavian Journal of Infectious Diseases·K Ganrot-Norlin
Sep 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·A M LernerM J Shippey
Oct 1, 1971·Archives of Neurology·H Link, R Müller
Nov 1, 1980·American Journal of Diseases of Children·T MorishimaS Suzuki

❮ Previous
Next ❯

Citations

Dec 1, 1990·Journal of Neurology·J HellerK Schimrigk
Jul 1, 1987·Journal of Clinical Immunology·I JulkunenO Mäkelä
Jan 1, 1985·Clinical Neurology and Neurosurgery·H H KampA Elderson
Jul 1, 1988·Pediatric Neurology·N IchibaH Kimoto
May 1, 1985·Journal of Neuroimmunology·I JulkunenA Vaheri
Apr 16, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·K MustonenM Koskiniemi
Oct 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·J Alvarez-CermeñoP González-Porque
Mar 29, 2003·Journal of Perinatal Medicine·Kirsi MustonenMarjaleena Koskiniemi
Apr 1, 1986·Acta Neurologica Scandinavica·P ForsbergC Orvell
Feb 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·B EstañolT Corona
Aug 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·G GlikmannC H Mordhorst
Aug 1, 1993·Acta Neurologica Scandinavica·R Kaiser, C H Lücking
Oct 22, 2008·The Medical Journal of Australia·Sanjaya N Senanayake

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.