Local production of the chemokines CCL5 and CXCL10 attracts CD8+ T lymphocytes into esophageal squamous cell carcinoma

Oncotarget
Jinyan LiuYi Zhang

Abstract

Esophageal squamous cell carcinoma (ESCC) is a very common malignant tumor with poor prognosis in China. Chemokines secreted by tumors are pivotal for the accumulation of CD8(+) T lymphocytes within malignant lesions in several types of cancers, but the exact mechanism underlying CD8(+) T lymphocyte homing is still unknown in ESCC. In this study, we revealed that, compared with marginal tissues, the expression of both chemokine (C-C motif) ligand 5 (CCL5) and (C-X-C motif) ligand 10 (CXCL10) was upregulated in ESCC tissues. CCL5 expression was positively associated with the overall survival of patients. Meanwhile, RT-PCR data showed that the expression of CCL5 and CXCL10 was positively correlated with the local expressions of the CD8(+) T lymphocyte markers (CD8 and Granzyme B) in tumor tissues. Correspondingly, CD8(+) T lymphocytes were more frequently CCR5- and CXCR3-positive in tumor than in peripheral blood. Transwell analysis showed both CCL5 and CXCL10 were important for the chemotactic movement of CD8(+) T lymphocytes. Our data indicate that CCL5 and CXCL10 serve as the key chemokines to recruit CD8(+) T lymphocytes into ESCC tissue and may play a role in patient survival.

References

Jul 2, 2004·Nature Reviews. Cancer·Fran Balkwill
Apr 28, 2005·International Journal of Cancer. Journal International Du Cancer·Hiroaki MushaIwao Sasaki
Dec 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eiichi SatoKunle Odunsi
Feb 10, 2006·The New England Journal of Medicine·Israel F Charo, Richard M Ransohoff
Jan 11, 2007·Cancer Research·Uma ThanarajasingamRichard G Vile
Jun 2, 2007·The Lancet Oncology·Christophe MarietteJean-Pierre Triboulet
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Andor PivarcsiBernhard Homey
Mar 19, 2009·Cancer Research·Helena HarlinThomas F Gajewski
Jan 10, 2012·The American Journal of Pathology·Greg ParsonageSteven P Lee
Jan 13, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·D HangW-G Xu
May 29, 2012·Immunity·Albert Zlotnik, Osamu Yoshie
Dec 6, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anna Marie MulliganIrene L Andrulis
Dec 12, 2012·Cancer Research·Katarzyna FranciszkiewiczFathia Mami-Chouaib
Apr 20, 2013·Nature Reviews. Immunology·David Masopust, Jason M Schenkel
May 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Telma LançaBruno Silva-Santos
Jun 20, 2013·The Journal of Clinical Investigation·Chunyan Gu-TrantienKaren Willard-Gallo
Jul 23, 2013·International Journal of Cancer. Journal International Du Cancer·Elise P SalernoCraig L Slingluff
Aug 30, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Andreas A HombachHinrich Abken
Oct 1, 2013·Journal of Translational Medicine·Michael TachezyMaximilian Bockhorn
Oct 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Daisuke SugiyamaShimon Sakaguchi
Mar 1, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fayçal DjenidiFathia Mami-Chouaib

❮ Previous
Next ❯

Citations

Apr 10, 2017·Cancer Immunology, Immunotherapy : CII·Gülçin GezginMartine J Jager
Jun 22, 2019·Molecular Cancer·Lifeng LiYi Zhang
May 15, 2020·Scientific Reports·Sladjana Skopelja-GardnerKeith B Elkon
Jul 8, 2018·International Journal of Cancer. Journal International Du Cancer·Xinfeng ChenYi Zhang
Feb 27, 2020·Journal for Immunotherapy of Cancer·Feng LiYi Zhang
Dec 25, 2015·The Journal of Biological Chemistry·Inga KretschmerJens W Fischer
Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Takouhie MgrditchianBassam Janji
Aug 7, 2018·International Journal of Particle Therapy·Penny FangSteven H Lin
Dec 21, 2017·Intractable & Rare Diseases Research·Xiaodan ZhengChengfang Yao
Jan 25, 2020·International Journal of Molecular Sciences·Marlene Bravo-ParraVerónica Mata-Haro
Feb 12, 2017·Cell Death and Differentiation·Elisabetta PalazzoMaria I Morasso
Mar 22, 2018·Scientific Reports·Jhajaira M AraujoJoseph A Pinto
Nov 28, 2019·Esophagus : Official Journal of the Japan Esophageal Society·Masakazu Goto, Mingyao Liu
Sep 17, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Asel BiktasovaNatalia Issaeva
Jan 23, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joan M RomeroSteven Gallinger
Jan 16, 2021·The Urologic Clinics of North America·Boris A RevaAshutosh K Tewari
Jan 27, 2021·Cytokine & Growth Factor Reviews·Xue Yao, Sandro Matosevic
Mar 1, 2021·Pathology, Research and Practice·Negar KhoshghamatAmir Avan
Aug 17, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Abdolreza OsaliAbdolreza Esmaeilzadeh

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry

Software Mentioned

ImageJ
GraphPad
GraphPad Prism

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.