Local properties of CA1 region in hippocampo-prefrontal synaptic plasticity in rats

Neuroreport
Y IzakiMasahiko Nomura

Abstract

We studied paired-pulse facilitation and long-term potentiation/depression in anesthetized rats to determine whether the hippocampal CA1 region inhibits local differences in short-term and long-term synaptic plasticity in its projections to the prefrontal cortex. We compared projections with the PFC from the posterior dorsal and ventral hippocampal CA1 regions (pdCA1 and vCA1 respectively). The two pathways displayed similar properties. However, the PPF properties of the pdCA1, projections differed dramatically from those of the pdCA1 projections. The pdCA1 projections showed the opposite of facilitation (i.e. suppression) at 25-50 ms intervals and more pronounced facilitation at 100-400 ms intervals. These results suggest that there are functional differences between these pathways.

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Citations

May 17, 2003·Neuroscience Letters·Yoshinori IzakiTatsuo Akema
Jan 11, 2008·Neuroreport·Yoshinori IzakiTatsuo Akema
Dec 10, 2009·Neuroreport·Masatoshi TakitaMichiko Ohtomi
Jun 11, 2008·The European Journal of Neuroscience·Yoshinori IzakiTatsuo Akema
Jul 2, 2003·Journal of Pharmacological Sciences·Satoshi OhashiMitsuhiro Yoshioka
Jan 15, 2017·Physiological Reports·Lezio S Bueno-JuniorOsvaldo D Uchitel
Dec 24, 2018·Journal of Neurophysiology·Thomas McColganRichard Kempter
Jul 18, 2014·Learning & Memory·Philip A VieiraEdward Korzus

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