Abstract
1. The aim of the present brief review is to show that the pulsatile component of blood pressure is a stronger determinant of large artery remodelling than the steady component (i.e. mean blood pressure). 2. Pulse pressure, which is a strong determinant of cardiovascular events, including coronary heart disease and stroke, is increased when large arteries stiffen. Local pulse pressure, measured with applanation tonometry in normotensives and patients with essential hypertension, explains a significant part of the variance of intima-media thickness at the site of the carotid artery, a proximal elastic artery, whereas mean blood pressure does not contribute. Local pulse pressure has no influence on intima-media thickness at the site of the radial artery, a distal muscular artery that undergoes very little stroke change in diameter. 3. The decrease in carotid pulse pressure is also a major determinant of the regression of carotid intima-media thickness after antihypertensive treatment. Local pulse pressure can influence not only intima-media thickness, but also internal diameter. Indeed, there is a significant association between the lumen enlargement of the ascending aorta in patients with Marfan syndrome and pulse pressure. In a...Continue Reading
References
Feb 6, 1976·Science·D Y LeungM B Mathews
Feb 1, 1991·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·Y TardyM Arditi
Apr 1, 1989·Hypertension·B DarneL Guize
May 12, 1994·The New England Journal of Medicine·J ShoresR E Pyeritz
Nov 1, 1996·Circulation Research·P ReuschH E Ives
Jan 1, 1997·Ultrasound in Medicine & Biology·A P HoeksR S Reneman
Dec 24, 1997·Hypertension·A BenetosL Guize
May 25, 1999·Circulation·G JondeauS Laurent
Sep 29, 1999·Circulation·P BoutouyrieS Laurent
Dec 11, 1999·Circulation Research·Y FengR T Lee
Jun 7, 2000·Circulation·P BoutouyrieS Laurent
May 23, 2001·Hypertension·S LaurentA Benetos
Citations
May 5, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ciro A Ruiz-FeriaHiroko Nishimura
Mar 26, 2013·Cardiovascular Research·Ratnadeep BasuZamaneh Kassiri
Oct 17, 2009·Journal of Biomechanical Engineering·Qingping YaoHai-Chao Han
Jun 5, 2012·Sleep Medicine Reviews·Craig L PhillipsAlberto P Avolio
Jul 19, 2005·Journal of Biomechanics·Rebecca J GusicKeith J Gooch
Mar 7, 2006·Progress in Cardiovascular Diseases·Axel LinkeRainer Hambrecht
Nov 4, 2005·Life Sciences·Shun-ichiro IzumiShinji Okuwaki
Apr 3, 2007·Journal of the American College of Cardiology·Iftikhar J Kullo, A Rauoof Malik
Sep 15, 2016·Physiological Reports·Jane M BlackJoseph I Esformes
Mar 13, 2018·Experimental Physiology·William E HughesDarren P Casey
Aug 7, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Laura L SchottKim Sutton-Tyrrell
Apr 26, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Daniel L MyersLucy Liaw
Aug 29, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Patricia EcheverríaEugenia Negredo