Local recurrence following surgical treatment for carcinoma of the lower rectum

ANZ Journal of Surgery
Adrian L PolglasePrithi S Bhathal

Abstract

The present paper examines the local recurrence rate following surgical treatment for carcinoma of the lower rectum with principally blunt dissection directed at tumour-specific mesorectal excision (including total mesorectal excision when appropriate). During the period April 1987-December 1999, 123 consecutive resections for carcinoma of the middle and distal thirds of the rectum were performed. The patients had low anterior resection, ultra low anterior resection or abdomino-perineal resection. Ninety-six eligible patients underwent curative resection. The mean follow-up period was 66.8 months +/-44.3 (range 3-176 months). Data were available on all patients having been prospectively registered and retrospectively collated and computer coded. The overall rate of local recurrence was 5.2% (four recurrences following ultra low anterior resection and one following abdomino-perineal resection. No local recurrence occurred after low anterior resections.). Local recurrences occurred between 16 and 52 months from the time of resection, and the cumulative risk of developing local recurrence at 5 years for all patients was 7.6%. The overall 5-year cancer specific survival of the 96 patients was 80.8%, and the overall probability of b...Continue Reading

References

Jan 1, 1980·The British Journal of Surgery·E S HughesA L Polglase
Jul 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R J Heald
Feb 20, 1993·Lancet·J K MacFarlaneR J Heald
Feb 20, 1993·Lancet·L P Fielding
May 15, 1993·Lancet·W Silen
Jan 1, 1996·The British Journal of Surgery·R J Nicholls, C Hall
Feb 1, 1996·The British Journal of Surgery·R J Aitken
May 1, 1997·The British Journal of Surgery·P J HainsworthW J Cunliffe
Jun 2, 1998·The British Journal of Surgery·E CarlsenR J Heald
Jun 24, 1998·Annals of Surgery·S ZaheerD Ilstrup
Mar 4, 2000·Journal of the National Cancer Institute·D G Haller
Aug 8, 2001·The British Journal of Surgery·D HayneP B Boulos
Nov 20, 2002·ANZ Journal of Surgery·Alan P Meagher, Robyn L Ward

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Citations

Apr 20, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S JeyarajahUNKNOWN Leicester Colorectal Specialist Group
Oct 30, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S-L HanJ-Y Yan

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