Local release of gemcitabine via in situ UV-crosslinked lipid-strengthened hydrogel for inhibiting osteosarcoma

Drug Delivery
Wei WuWenguo Cui

Abstract

Osteosarcoma is among the most common malignant bone tumors in human skeletal system. The conventional treatment of osteosarcoma mainly consists of combining neoadjuvant chemotherapy with surgical approach. However, it is crucial to design an artificial implant that possesses excellent biomechanical properties and is capable of sustaining local release of chemotherapeutics. In this study, we envision that the highly efficient combination of gemcitabine (GEM) hydrochloride loaded liposomes with gelatin methacryloyl (GelMA) of in situ photocrosslinkable hydrogel will lead to a multifunctional implant with unique antitumor, mechanical, and biodegradable properties. A sustained controlled release was observed; more specifically, the release of GEM in vitro lasted for 4 days long. Furthermore, its capability in killing MG63 cells was further explored by using the lixivium of GEM-Lip@Gel and GEM-GelMA hydrogel in vitro (composite hydrogel by GEM loaded liposomes blending with GelMA, short for GEM-Lip@Gel), which agreed with the drug release outcome. In addition, these hydrogel showed excellent ability in inhibiting osteosarcoma in vivo by Balb/c mice bearing MG63 cells. Therefore, GEM-loaded lipo-hydrogel certainly has presented itse...Continue Reading

References

Sep 1, 1991·The Journal of Bone and Joint Surgery. British Volume·P RobertsJ T Scales
Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·M CerutiL Cattel
May 16, 2000·Clinical Orthopaedics and Related Research·M RyttingN Jaffe
Apr 16, 2002·Clinical Orthopaedics and Related Research·Bruno Fuchs, Douglas J Pritchard
Oct 29, 2004·Plastic and Reconstructive Surgery·Sukru YazarFu-Chan Wei
Nov 30, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maria Laura ImmordinoLuigi Cattel
Jan 5, 2005·The Laryngoscope·Charles J LimbJohn K Niparko
Jul 5, 2005·The Journal of Trauma·Tamon KabataKasuro Tomita
Jul 25, 2006·Cancer Treatment Reviews·Alessandra LonghiGaetano Bacci
Sep 14, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yoon YeoMilica Radisic
Feb 14, 2009·Cancer Metastasis Reviews·Hang T TaDave E Dunstan
Feb 27, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Donatella PaolinoMassimo Fresta
Mar 10, 2010·Cancer Treatment and Research·Giulia Ottaviani, Norman Jaffe
Nov 23, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Xiao-Qiu DouChuan-Liang Feng
Nov 21, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cheng WangShiyong Liu
Feb 1, 2017·ACS Applied Materials & Interfaces·Hao ChengAli Khademhosseini
Jun 29, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roxana Cristina PopescuDiana Savu
Nov 17, 2017·ACS Applied Materials & Interfaces·Tianwen XinLiang Chen

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Citations

Jul 19, 2020·Journal of Biomedical Materials Research. Part a·Bowen TanJinfeng Liao
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Mural QuadrosGunjan Verma
Mar 18, 2021·Bone Research·Jinfeng LiaoZhiyong Qian
Nov 6, 2020·International Journal of Pharmaceutics·Shweta ParohaPrashant Kesharwani

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