PMID: 9555034May 16, 1998Paper

Local renin-angiotensin system in the pineal gland

Brain Research. Molecular Brain Research
O BaltatuM Bader

Abstract

Besides the classical endocrine renin-angiotensin system (RAS), a local RAS has been described also in the brain. We attempted to clarify the existence of a local RAS in the pineal gland. Through the use of a ribonuclease protection assay, it proved possible to detect the mRNA for angiotensinogen (AOGEN), for the angiotensin receptor type 1A (AT1a) and 1B (AT1b) and for the angiotensin-converting enzyme (ACE) in pineal glands from rats. Renin mRNA, however, could not be found by this method. By in situ hybridization and immunocytochemistry, AOGEN mRNA was co-localized with the astrocyte marker glial fibrillary acidic protein. AT1b mRNA expression exceeded the expression of AT1a mRNA and was co-localized with the pinealocyte-specific tryptophan hydroxylase. Thus, in the mammalian pineal gland there is a local formation of the components of the RAS. The presence of angiotensin II receptors further substantiates a role for angiotensins and the pineal RAS in the physiology of this gland.

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Citations

Jun 5, 2002·Physiology & Behavior·Ronaldo C AraujoJorge L Pesquero
Apr 8, 2010·American Journal of Physiology. Endocrinology and Metabolism·Lijun ShiZhice Xu
Mar 28, 2009·Regulatory Peptides·Hans ImbodenJuan M Saavedra
Mar 11, 2008·Experimental Physiology·Zhiying ShanMohan K Raizada
Apr 16, 2008·Journal of Neurochemistry·Nadia de MotaCatherine Llorens-Cortes
Feb 1, 2013·International Journal of Hypertension·Luciana A CamposOvidiu C Baltatu
Jul 29, 2015·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Amanda A RibeiroDulce E Casarini
Jul 4, 2006·Physiological Reviews·Martin PaulReinhold Kreutz
Jan 18, 2002·Journal of Applied Physiology·Eugene C FletcherMichael Bader
Jan 25, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Julio Cesar BorgesJorge Luiz Pesquero
Dec 13, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Luciana A CamposOvidiu C Baltatu
Jan 6, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Naro OhashiShinsuke Isobe
Oct 25, 2002·Journal of the American Society of Nephrology : JASN·Ovidiu BaltatuMichael Bader
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmet Ozer SehirliNedime Serakinci

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