Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys.

Retrovirology
Sallie R PermarNorman L Letvin

Abstract

Breast milk transmission remains a major mode of infant HIV acquisition, yet anatomic and immunologic forces shaping virus quasispecies in milk are not well characterized. In this study, phylogenic analysis of envelope sequences of milk SIV variants revealed groups of nearly identical viruses, indicating local virus production. However, comparison of the patterns and rates of CTL escape of blood and milk virus demonstrated only subtle differences between the compartments. These findings suggest that a substantial fraction of milk viruses are produced by locally-infected cells, but are shaped by cellular immune pressures similar to that in the blood.

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Citations

Dec 31, 2010·Journal of Virology·Jesus F Salazar-GonzalezUNKNOWN Center for HIV/AIDS Vaccine Immunology A0167854
Sep 3, 2011·PloS One·Tatenda MahlokozeraUNKNOWN Center for HIV/AIDS Vaccine Immunology
Sep 3, 2010·PLoS Pathogens·Jeffrey A AndersonUNKNOWN Center for HIV/AIDS Vaccine Immunology
Jun 19, 2013·Immunological Reviews·Lianna F WoodDonald L Sodora
Aug 26, 2014·The Journal of General Virology·Cecilia T Costiniuk, Mohammad-Ali Jenabian
May 2, 2015·PloS One·Xiaowen LuMartijn A Huynen
Jul 11, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kevin RaehtzCristian Apetrei
Nov 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew B WilksSallie R Permar

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Datasets Mentioned

BETA
D01065

Methods Mentioned

BETA
PCR
SGA

Software Mentioned

ClustalW
HYPHY
PhyML
MrBayes

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