Local sustained-release delivery systems of the antibiofilm agent thiazolidinedione-8 for prevention of catheter-associated urinary tract infections

International Journal of Pharmaceutics
Julia ShenderovichM Friedman

Abstract

Thiazolidinedione-8 (TZD-8) is an anti-quorum-sensing molecule that has the potential to effectively prevent catheter-associated urinary tract infections, a major healthcare challenge. Sustained-release drug-delivery systems can enhance drugs' therapeutic potential, by maintaining their therapeutic level and reducing their side effects. Varnishes for sustained release of TZD-8 based on ethylcellulose or ammonio methacrylate copolymer type A (Eudragit(®) RL) were developed. The main factors affecting release rate were found to be film thickness and presence of a hydrophilic or swellable polymer in the matrix. The release mechanism of ethylcellulose-based systems matched the Higuchi model. Selected varnishes were retained on catheters for at least 8 days. Sustained-release delivery systems of TZD-8 were active against Candida albicans biofilms. The present study demonstrates promising results en route to developing applications for the prevention of catheter-associated infections.

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Citations

Feb 24, 2016·Frontiers in Microbiology·Mark FeldmanDoron Steinberg
Jan 17, 2016·Current Opinion in Biotechnology·Sivan Nir, Meital Reches
Jul 28, 2016·Expert Opinion on Drug Delivery·Doron Steinberg, Michael Friedman
Dec 19, 2017·Journal of Drug Targeting·Rahul MittalKusum Harjai
Nov 24, 2018·Journal of Biomedical Materials Research. Part a·Zhiling ZhuXun Yuan
Mar 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Koon Gee NeohPaul Anantharajah Tambyah
Mar 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nazar TrotskoMonika Wujec
Mar 23, 2018·Frontiers in Pharmacology·Benjamin RémyDavid Daudé
Jun 21, 2018·Molecular Pharmaceutics·Alice CraneHui Zhu

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