Aug 1, 1977

Local synovial synthesis of oligoclonal measles virus antibodies and of smooth muscle antibodies in a case of atypical rheumatoid arthritis

Annals of the Rheumatic Diseases
B VandvikE Norrby


A patient with atypical rheumatoid arthritis (RA) and local synovial synthesis of oligoclonal IgG in an arthritic knee joint is described. Measles virus-specific antibodies isolated from the synovial fluid (SF) were carried by oligoclonal IgG proteins but constituted only a fraction of the total oligoclonal IgG of the SF. Smooth muscle antibodies were markedly increased in the SF compared with the serum and were associated with an electrophoretically restricted fraction of IgG. The results indicate that a local synovial synthesis of measles virus-specific antibodies and of smooth muscle antibodies occurred within the affected joint in our patient.

Mentioned in this Paper

Measles virus
Antibodies, Viral
Smooth Muscle
Synovial Fluid
Antibody Formation
Rheumatoid Arthritis
Knee Joint
Measles virus preparation
Entire Knee Joint
Edmonston virus

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