Local temporal variability reflects functional integration in the human brain

NeuroImage
Douglas D GarrettUlman Lindenberger

Abstract

Local moment-to-moment variability exists at every level of neural organization, but its driving forces remain opaque. Inspired by animal work demonstrating that local temporal variability may reflect synaptic input rather than locally-generated "noise," we used publicly-available high-temporal-resolution fMRI data (N = 100 adults; 33 males) to test in humans whether greater BOLD signal variability in local brain regions was associated with functional integration (estimated via spatiotemporal PCA dimensionality). Using a multivariate partial least squares analysis, we indeed found that individuals with higher local temporal variability had a more integrated (lower dimensional) network fingerprint. Notably, temporal variability in the thalamus showed the strongest negative association with PCA dimensionality. Previous animal work also shows that local variability may upregulate from thalamus to visual cortex; however, such principled upregulation from thalamus to cortex has not been demonstrated in humans. In the current study, we rather establish a more general putative dynamic role of the thalamus by demonstrating that greater within-person thalamo-cortical upregulation in variability is itself a unique hallmark of greater fun...Continue Reading

Citations

Nov 3, 2020·Journal of Cognitive Neuroscience·Peter R MillarDavid A Balota
Dec 18, 2020·ELife·Golia ShafieiBratislav Misic
Feb 18, 2021·Neuron·Leonhard WaschkeDouglas D Garrett
Apr 25, 2021·Nature Communications·Julian Q KosciessaDouglas D Garrett
Jul 27, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Manyoel LimAlexandre F DaSilva
Aug 18, 2021·Communications Biology·Mehrshad GolesorkhiGeorg Northoff
Aug 27, 2021·NeuroImage. Clinical·Angela M Muller, Dieter J Meyerhoff
Oct 14, 2021·Scientific Reports·Kelly ShenAnthony R McIntosh

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