Local therapy for rhabdomyosarcoma of the hands and feet: is amputation necessary? A report from the Children's Oncology Group.

International Journal of Radiation Oncology, Biology, Physics
Trang H LaSarah S Donaldson

Abstract

To evaluate the outcome of children with rhabdomyosarcoma (RMS) of the hand or foot treated with surgery and/or local radiotherapy (RT). Forty-eight patients with nonmetastatic RMS of the hand or foot were enrolled on Intergroup Rhabdomyosarcoma Study III, IV-Pilot, and IV. Patients received multiagent chemotherapy with surgery and/or RT. Twenty-four patients (50%) underwent surgery without local RT, of whom 4 had complete resection and 20 had an amputation. The remaining 24 patients (50%) underwent local RT, of whom 2 required RT for microscopic residual disease after prior amputation. Median follow-up for surviving patients was 9.7 years. Actuarial 10-year local control was 100%; 10-year event-free survival and overall survival rates were 62% and 63%, respectively. Poor prognostic factors for recurrence included gross residual (Group III) disease and nodal involvement (p = 0.01 and 0.05, respectively). More patients in the RT group had alveolar histology, Group III disease, and nodal involvement, as compared with the surgery group. There was no difference in 10-year event-free survival (57% vs. 66%) or overall survival (63% vs. 63%) between patients who underwent surgery or local RT. Among relapsing patients, there were no lo...Continue Reading

References

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Citations

Mar 24, 2012·Journal of Cancer Research and Clinical Oncology·Yuki KojimaYasuhiro Fujiwara
Jan 18, 2012·Seminars in Pediatric Surgery·Roshni Dasgupta, David A Rodeberg
Nov 17, 2015·Hand : Official Journal of the American Association for Hand Surgery·Dana L CaseySarah S Donaldson
Dec 21, 2012·Pediatric Blood & Cancer·Douglas S HawkinsUNKNOWN COG Soft Tissue Sarcoma Committee
Dec 21, 2012·Pediatric Blood & Cancer·Thomas E MerchantUNKNOWN COG Radiation Oncology Discipline Committee
Aug 26, 2020·The Journal of the American Academy of Orthopaedic Surgeons·Talia Chapman, Edward Athanasian

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