PMID: 6169425Oct 15, 1981Paper

Local therapy of carcinoma of the uterine cervix: part I

Cancer
H MasudaK Nagai

Abstract

One-hundred-fifteen patients with cervical cancer were treated by placing bleomycin, carbazilquinone (Carboquone), and 5-fluorouracil suppositories in contact with cancer lesions located in the vaginal portion of the uterus or by inserting them into the cervical canal, twice a week, one to 14 times. The cancer lesions disappeared form 17 to 33 patients with Stage 0 lesions and 9 of 42 with Stage IA lesions. The remaining lesions were principally found in the deep portion of the cervical glands and tended to decrease the more often the suppositories were applied. This led to the presumption that if this local therapy had been carried on longer it would have eradicated even the remaining lesions from the patients with Stage 0 and IA lesions. The optimal per administration dose of bleomycin appeared to be 30 mg. The use of Witepsol (Dynamit Nobel Aktiengesellschaft, F.R.G.) suppository base was accompanied by frequent adverse reactions to it, which hindered the local therapy from being repeated over long periods of time. An equal amount mixture of hydroxypropyl cellulose and carbomer (Carbopol 934) as the suppository base was accompanied by relatively less adverse reactions, which permitted the prolonged local therapy with the sup...Continue Reading

References

Jun 1, 1978·Chemical & Pharmaceutical Bulletin·Y Machida, T Nagai
Oct 15, 1976·American Journal of Obstetrics and Gynecology·M J FeldmanM Nelson
Oct 15, 1970·American Journal of Obstetrics and Gynecology·R H KaufmanH J Spjut
Oct 28, 1961·JAMA : the Journal of the American Medical Association·J H FERGUSON

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Citations

Nov 2, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kiyoshi SatakeMasayuki Kimura
Jul 19, 2018·Occupational and Environmental Medicine·Aaron Blair, Lin Fritschi
Apr 16, 2021·Advanced Drug Delivery Reviews·Xue WangZhigang Xie

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