Local tissue electrical parameters predict oral mucositis in HNSCC patients: A diagnostic accuracy double-blind, randomized controlled trial.

Scientific Reports
Gabriela Luize Guimarães SanchesAndré Luiz Sena Guimarães

Abstract

Oral Mucositis (OM) is a common adverse effect of head and neck squamous cell carcinoma (HNSCC) treatment. The purpose of this study was to investigate the significance of early changes in tissue electrical parameters (TEPs) in predicting the development of OM in HNSCC patients receiving radiation therapy (RT). The current study combined two study designs. The first was a case-control study. The control group comprised of RT patients who did not receive head and neck RT, and patients with HNSCC who received RT comprised the case group. In the second part of the study, the case group was included in a parallel cohort. A total of 320 patients were assessed for eligibility, and 135 patients were enrolled. Double blinding was performed, and neither the patients nor the care providers knew the measured parameters. The primary outcome was the detection of between-group changes in local TEPs over the follow-up period. The secondary outcome was the appearance of OM grades II, III, or IV and the predictive value of local TEPs in determining the incidence of OM after RT. The variables, impedance module, resistance, reactance, phase angle, and capacitance, were analyzed by the receiver operator curves (ROC). The case and control groups di...Continue Reading

References

Jun 12, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A VissinkR P Coppes
Apr 27, 2004·Cancer·Stephen T SonisUNKNOWN International Society for Oral Oncology
Mar 1, 1997·Journal of Clinical Forensic Medicine·M Odell
Sep 24, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ursula G KyleUNKNOWN Composition of the ESPEN Working Group
Nov 24, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ursula G KyleUNKNOWN ESPEN
Apr 25, 2007·Annals of Plastic Surgery·Anne G WarrenLoren J Borud
Sep 20, 2008·Photomedicine and Laser Surgery·Luana CamposCarlos De Paula Eduardo
Jun 24, 2009·Deutsches Ärzteblatt International·Bernd RöhrigMaria Blettner
Mar 23, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Caroline M SpeksnijderRon Koole
May 19, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lester J PetersDanny Rischin
Sep 29, 2011·Oral Oncology·Carlos Alberto de Carvalho FragaAndré Luiz Sena Guimarães
Jan 13, 2012·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Thiago Fonseca-SilvaAndré Luiz Sena Guimarães
Jan 31, 2012·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Thiago Fonseca-SilvaAndré Luiz Sena Guimarães
Sep 25, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Cesar MiglioratiUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Jul 13, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jacqueline A E LangiusPeter J M Weijs
May 21, 2014·PharmacoEconomics·Erika WissingerChris L Pashos
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Mar 24, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·Alan E Nahum
Apr 11, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Teresa Małecka-MassalskaKamal Morshed
Jan 1, 2014·SpringerPlus·Patrícia Luciana Batista DomingosAndré Luiz Sena Guimarães
Jun 24, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ugo Borges PinheiroAndré Luiz Sena Guimarães
Dec 24, 2015·The Cochrane Database of Systematic Reviews·Philip RileyMartin G McCabe
Mar 6, 2016·Mayo Clinic Proceedings·Shanthi Marur, Arlene A Forastiere
Jun 8, 2017·Frontiers in Oncology·Osama Muhammad MariaThierry Muanza
Jul 5, 2017·Oral Diseases·R V LallaUNKNOWN OraRad Study Group
Oct 18, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A BrzozowskaT Małecka-Massalska
Nov 9, 2018·Pathology Oncology Research : POR·Marcela Gonçalves de SouzaAndré Luiz Sena Guimarães
Nov 21, 2018·Oral and Maxillofacial Surgery Clinics of North America·William M MendenhallRui P Fernandes

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