PMID: 7525741May 1, 1993Paper

Local tolerance to subcutaneous infusions of high concentrations of hydromorphone: a prospective study

Journal of Pain and Symptom Management
E BrueraJ Hanson

Abstract

In a prospective open study, 24 patients with cancer pain receiving parenteral opioids were administered highly concentrated solutions of hydromorphone in order to assess the local tolerance to the subcutaneous infusion. Patients received a mean concentration of hydromorphone of 30 +/- 15 mg/mL at a mean rate of infusion of 0.3 +/- 0.25 mL/hr. Of 22 evaluable patients, 17 (77%) had a site duration of more than 7 days with their first subcutaneous site (mean concentration of 34 +/- 8 mg/mL of hydromorphone). Four of the five remaining patients (80%) had site duration of more than 7 days with their second subcutaneous site. Only one patient (5%) did not reach a 7-day duration after three consecutive site changes. Out of 7 subcutaneous sites that presented signs of toxicity before 7 days of infusion, the main problem was erythema in three cases, swelling in two cases, and bleeding in two cases. All sites improved spontaneously and did not require any medical treatment. No correlation was found between the concentration or rate of infusion of hydromorphone and the duration of the subcutaneous site. The duration of the site was significantly correlated with weight, tricep skinfold, subscapular skinfold, and age of the patients. Our ...Continue Reading

References

Aug 1, 1990·Journal of Pain and Symptom Management·E BrueraM J Miller

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Citations

Jul 1, 1995·Journal of Pain and Symptom Management·N D de StoutzM Suarez-Almazor
May 24, 2005·Journal of Pain and Symptom Management·Alison Murray, Neil A Hagen
Jul 9, 1998·Journal of Pain and Symptom Management·U Zachrisson, C J Fürst
Jan 1, 2009·Journal of Palliative Medicine·Henrique A ParsonsEduardo Bruera
Aug 24, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Wendy H OldenmengerAgnes Jager
Apr 29, 2014·Journal of Pain and Symptom Management·Lena BartzStephanie Stiel
Jun 29, 2011·Palliative Medicine·Alessandra PigniAugusto Caraceni
Jun 18, 2002·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M ZhengM C Ong
Mar 1, 2002·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M ZhengM C Ong

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