Local Treatment of Metastatic Prostate Cancer: What is the Evidence So Far?

Prostate Cancer
Pedro Leonel Almeida, Bruno Jorge Pereira

Abstract

Advances in technological, laboratorial, and imaging studies and new treatments available in the last decades significantly improved prostate cancer survival rates. However, this did not occur in metastatic prostate cancer (mPCa) at diagnosis which, in young and fit patients, will become invariably resistant to the established treatments. Progression will lead to an impairment in patients' quality of life and disease-related death. The authors intend to perform a literature review of the advantages of primary treatment of mPCa. Articles were retrieved and filtered for relevance from PubMed, SciELO, and ScienceDirect until March 2017. Primary treatment is currently indicated only in cases of nonmetastatic PCa. Nonetheless, there might be some benefits in doing local treatment in mPCa in order to control local disease, prevent new metastasis, and improve the efficacy of chemotherapy and hormonotherapy with similar complications rate when compared to locally confined cancer. Independent factors that have a negative influence are age above 70 years, cT4 stage or high-grade disease, PSA ≥ 20 ng/ml, and pelvic lymphadenopathies. The presence of 3 or more of these factors conditions CSS and OS is the same between patients who performe...Continue Reading

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Nov 22, 2019·PLoS Computational Biology·Stefano Avanzini, Tibor Antal
Jun 29, 2018·Journal of Biomolecular Structure & Dynamics·Farheen WaziriSaima Wajid
Nov 22, 2019·Scandinavian Journal of Caring Sciences·Mette Margrethe Løwe Netsey-AfedoRegner Birkelund
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Sep 22, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sangeeta Ray BanerjeeMartin G Pomper

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