Local tumor progression following lipiodol-based targeted chemoembolization of hepatocellular carcinoma: a retrospective comparison of miriplatin and epirubicin.

Cancer Management and Research
Jin IwazawaTakashi Mitani

Abstract

We aimed to compare the local control rates between miriplatin and epirubicin in lipiodol-based transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). Patients who underwent targeted TACE using miriplatin (47 patients, 66 lesions) or epirubicin (64 patients, 79 lesions) as the sole therapy were enrolled. The local control rates were compared using the Kaplan-Meier estimator with the log-rank test. The patient and tumor parameters were subjected to univariate and multivariate analyses using the Cox proportional hazards model. The overall local recurrence rates were 39.3% and 31.6% for the miriplatin and epirubicin groups, respectively. The local control rate was significantly higher in the epirubicin group than in the miriplatin group (P < 0.001). The local control rates at 6 months and 1 year were 70.7% and 44.8% for the miriplatin group and 83.4% and 69.2% for the epirubicin group, respectively. Multivariate analysis showed that the serum α-fetoprotein level ≥ 20 ng/mL (hazard ratio 2.96; P < 0.001), miriplatin usage (hazard ratio 2.53; P = 0.002), and Child-Pugh class B (hazard ratio 1.89; P = 0.042) affected local progression. Lipiodol-based targeted TACE using miriplatin had inferior local control rates ...Continue Reading

References

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Jul 14, 2010·Journal of Vascular and Interventional Radiology : JVIR·Tomokazu KawaokaKazuaki Chayama

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Citations

Dec 25, 2012·Journal of Vascular and Interventional Radiology : JVIR·Nicholas J PetruzziDaniel B Brown
Apr 5, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jin IwazawaTakashi Mitani
Aug 21, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takahiro HandaSatoshi Mochida
Jan 9, 2016·Experimental Biology and Medicine·Ying ZhangYong Sun
Jun 29, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kousuke KubotaWasaburo Koizumi
Oct 14, 2014·World Journal of Gastroenterology : WJG·Satoru MurataShin-ichiro Kumita

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