PMID: 6167502Aug 6, 1981Paper

Local use of aprotinin in neurosurgical operations for the prevention of hyperfibrinolytic hemorrhage

Fortschritte der Medizin
D Giromini, T Tzonos

Abstract

The local use of a commercial solution of the proteinase inhibitor aprotinin (Trasylol) prevents a premature fibrinolysis which may lead to post-operative hyperfibrinolytic bleeding. Among 1.236 neurosurgical patients in whom aprotinin was routinely locally applied there were 8 cases of post-operative bleeding (0,6%). In 7 of these cases an impaired coagulation had been previously found or was found during surgery. The intra-operative use of Trasylol appears to be suited to reduce the rate of post-operative haemorrhagic complications in neurosurgery.

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