PMID: 39963Nov 1, 1979

Local xenogeneic graft-vs-host reaction: a practical assessment of T cell function among cancer patients

The Journal of Immunology : Official Journal of the American Association of Immunologists
G MavligitW Wong

Abstract

The local xenogeneic graft-vs-host reaction (XGVHR) was used as a practical bioassay to assess T lymphocyte function and immunocompetence among cancer patients. Positive XGVHR was found in 99.5% of normal donors, 70% of cancer patients with early stage disease, and 30% of cancer patients with metastatic disease (p less than 0.001). A minimum of 4.5 x 10(6) immunocompetent T lymphocytes are necessary in order to elicit a positive XGVHR. Negative reactions among cancer patients are characterized by the lack of edema fluid accumulation and the appearance of the most basophils at the test site. This suggests that insufficient amounts of lymphokines are being released by the incompetent T lymphocytes, whereas the host is capable of mounting a rejection reaction as evidenced by the appearance of the basophils. Preliminary evidence suggests that the immunologic defect detected by the XGVHR cannot be corrected by monocyte depletion. The identification of putative suppressor T cell subsets may bear immunotherapeutic implications in the future.

Related Concepts

Dermatofibrosarcoma Protuberans
T-Lymphocyte
TNM Staging System
Immune System Diseases
Basophils
SpecimenType - Basophils
Lymphoid Cells
Graft Vs Host Reaction
Dose-Response Relationship, Immunologic
Recombinant Lymphokine

Related Feeds

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.