PMID: 6169388Oct 10, 1981Paper

Localisation of malignant germ-cell tumours by external scanning after injection of radiolabelled anti-alpha-fetoprotein

British Medical Journal
A K HalsallK R Hine

Abstract

Sheep IgG antibody to alpha-fetoprotein was labelled with 131I and used to identify human germ-cell tumours by emission scanning. Eleven patients were studied after resection of their primary tumours. Ten had malignant teratoma and one an endodermal sinus tumour. All eight patients with raised serum alpha-fetoprotein concentrations had metastases apparent in the antibody scans. Of the remaining three patients with normal serum alpha-fetoprotein concentrations, two had positive scans. Three of the patients with positive results were scanned twice; the second scans were negative after treatment, when the alpha-fetoprotein concentrations had returned to normal. These result suggest that antibody scans are useful in the clinical management of patients with germ-cell tumours.

Citations

Jan 1, 1986·European Journal of Nuclear Medicine·R B RichardsonH B Coakham
Aug 20, 1991·European Journal of Obstetrics, Gynecology, and Reproductive Biology·L F MassugerF H Corstens
Jan 1, 1984·The Journal of Laryngology and Otology·R M TranterS Chandler
Jul 16, 1983·British Medical Journal·D S FairweatherS Chandler
Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·S H de BieF J Cleton
Sep 1, 1987·The British Journal of Radiology·S T Chandler, P Anderson
Dec 1, 1986·The British Journal of Radiology·C E ChapmanA R Bradwell
Dec 1, 1986·Cancer Treatment Reviews·H P Kalofonos, A A Epenetos
Jul 1, 1983·Clinical Radiology·E M Sweet
Mar 1, 1985·Cancer·A A EpenetosJ S Malpas
Oct 1, 1984·The British Journal of Surgery·R M Rainsbury
Jan 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E SpringoloJ Levin
Jun 1, 1983·Clinical Endocrinology·D S FairweatherR Hoffenberg
Nov 1, 1983·The Journal of Pathology·D S FairweatherP W Dykes
Apr 15, 1984·International Journal of Cancer. Journal International Du Cancer·K OhkawaH Hirai
Jan 1, 1988·La Ricerca in Clinica E in Laboratorio·R W BaldwinM V Pimm
Jan 1, 1988·International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement·A AthanassiouA Epenetos
Jan 1, 1988·Critical Reviews in Oncology/hematology·J L Murray, M W Unger
Sep 1, 1985·Current Problems in Cancer·J L Grosfeld, D F Billmire

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