Localisation of the Fanconi anaemia complementation group A gene to chromosome 16q24.3

Nature Genetics
J C PronkS Jansen

Abstract

Fanconi anaemia (FA) is an autosomal recessive disorder associated with diverse developmental abnormalities, bone-marrow failure and predisposition to cancer. FA cells show increased chromosome breakage and hypersensitivity to DNA cross-linking agents such as diepoxybutane and mitomycin C. Somatic-cell hybridisation analysis of FA cell lines has demonstrated the existence of at least five complementation groups (FA-A to FA-E), the most common of which is FA-A. This genetic heterogeneity has been a major obstacle to the positional cloning of FA genes by classical linkage analysis. The FAC gene was cloned by functional complementation, and localised to chromosome 9q22.3 (ref. 2), but this approach has thus far failed to yield the genes for the other complementation groups. We have established a panel of families classified as FA-A by complementation analysis, and used them to search for the FAA gene by linkage analysis. We excluded the previous assignment by linkage of an FA gene to chromosome 20q, and obtained conclusive evidence for linkage of FAA to microsatellite markers on chromosome 16q24.3. Strong evidence of allelic association with the disease was detected with the marker D16S303 in the Afrikaner population of South Afri...Continue Reading

References

Jun 1, 1992·Nature Genetics·C A StrathdeeM Buchwald
Aug 1, 1987·American Journal of Medical Genetics·J RosendorffT Jenkins
Jan 1, 1985·Somatic Cell and Molecular Genetics·G Duckworth-RysieckiM Buchwald
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M LathropJ Ott
Nov 1, 1981·Tissue Antigens·B O Bengtsson, G Thomson
Jun 1, 1994·Nature Genetics·G GyapayJ Weissenbach

❮ Previous
Next ❯

Citations

May 10, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Shamim I AhmadSandra H Kirk
Jul 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Digweed, K Sperling
Jan 1, 1997·Somatic Cell and Molecular Genetics·P M JakobsM Grompe
Sep 4, 2001·International Journal of Hematology·T Yamashita, T Nakahata
Nov 1, 1995·Nature Genetics·M Buchwald
Nov 1, 1996·Nature Genetics·A D D'Andrea
Nov 1, 1996·Nature Genetics·J R Lo Ten FoeH Joenje
Nov 1, 1996·Nature Genetics·UNKNOWN Fanconi anaemia/Breast cancer consortium
Feb 1, 1997·Human Molecular Genetics·W LiebetrauH Hoehn
Mar 24, 1999·Current Opinion in Hematology·I Garcia-HigueraA D D'Andrea
Apr 16, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Nabil N MoghrabiC Sue Richards
Jun 5, 2002·Genome Research·Diana HallMaria Karayiorgou
Feb 12, 1998·The Journal of Clinical Investigation·Y Li, H Youssoufian
Apr 27, 2013·PloS One·Anneke HaitjemaJosephine C Dorsman
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·A J TippingC G Mathew
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·O LevranA D Auerbach
Dec 19, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Maria KarayiorgouJ Louw Roos
Apr 17, 1999·American Journal of Human Genetics·Q WaisfiszM Digweed
Oct 23, 1997·American Journal of Human Genetics·H JoenjeF Arwert
Oct 13, 2000·Baillière's Best Practice & Research. Clinical Haematology·I Dokal
May 31, 2017·Genetics and Molecular Biology·Anna GueiderikhJanuario B C Neto
Jan 22, 2009·Annals of the New York Academy of Sciences·Johannes Lodewikus RoosMaria Karayiorgou
Mar 31, 1999·British Journal of Cancer·A M Cleton-JansenC J Cornelisse
Jun 5, 2001·Nature Reviews. Genetics·H Joenje, K J Patel
Jun 11, 1999·Journal of Pediatric Hematology/oncology·R E GoldsbyC S Bruggers
Jun 27, 2003·Journal of Human Genetics·Chiraz BouchlakaUNKNOWN Tunisian Fanconi Anemia Study Group
Jan 1, 1997·Genetic Testing·A D Auerbach
Apr 26, 2017·Molecular Medicine Reports·Sakineh Abbasi, Mina Rasouli
Oct 26, 1999·Biochemical and Biophysical Research Communications·M H RamirezM Schweiger
Nov 20, 2013·Seminars in Hematology·Payal P Khincha, Sharon A Savage
Aug 28, 2014·SpringerPlus·Anneke HaitjemaJosephine C Dorsman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.