Localised and sustained intradermal delivery of methotrexate using nanocrystal-loaded microneedle arrays: Potential for enhanced treatment of psoriasis.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Ismaiel A TekkoRyan F Donnelly

Abstract

Methotrexate (MTX), typically used as its sodium salt (MTX Na), is a first-line treatments for moderate to severe psoriasis, showing good efficacy. However, its systemic administration is associated with many side effects. Intradermal delivery into psoriatic tissue could offer an alternative approach. However, successful intradermal administration of MTX Na is currently precluded by its physicochemical properties. Moreover, due to its hydrophilic nature, MTX Na is swiftly cleared from the target tissue, necessitating frequent dosing which may affect patient compliance. To address these limitations, we investigated the combination of nanocrystal (NC) and dissolving microneedle (MN) technologies as an alternative approach for localised and sustained intradermal delivery of MTX Na. Poorly water-soluble MTX nanocrystals (MTX NC) were produced by a bottom-up technique with a mean particle size of 678 ± 15 nm. Sustained in vitro drug release was observed over 72 h. The MTX NC were then incorporated into the shafts of dissolving MN arrays with a drug loading of 2.48 mg/array. The MTX NC-loaded MN arrays exhibited satisfactory mechanical strength and insertion capabilities in the skin-simulant Parafilm M® and their shafts dissolved ent...Continue Reading

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Citations

Jan 4, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Suman PahalPraveen Kumar Vemula
Dec 29, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Lalit K VoraRyan F Donnelly
Apr 26, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ling LiangXin Dong Guo
May 11, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Satish RojekarRyan F Donnelly
Jun 3, 2021·International Journal of Molecular Sciences·Robert Gironés PetitElena Sánchez-López
May 30, 2021·International Journal of Pharmaceutics·Lijing ZhangPeng Zhang
Jun 15, 2021·International Journal of Biological Macromolecules·Srividya GorantlaGautam Singhvi
Jul 25, 2021·Drug Delivery and Translational Research·Alyaa A AlbadrRaghu Raj Singh Thakur
Jul 17, 2021·International Journal of Pharmaceutics·Alejandro J ParedesRyan F Donnelly
Jul 21, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mengzhen XingYunhua Gao
Jul 16, 2021·Drug Discovery Today·Prashantkumar K ParmarArvind K Bansal

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Methods Mentioned

BETA
X-ray
biopsy
imaging technique

Software Mentioned

ImageJ®
Agilent Open LAB Chromatography Data System
GraphPad Prism®
Excel
GraphPad
DD solver

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