PMID: 9189874May 1, 1997Paper

Localised proton MR spectroscopy of brain metabolism changes in vegetative patients

Neuroradiology
R RicciN Basaglia

Abstract

We examined 14 vegetative brain-injured patients with proton magnetic resonance single-volume spectroscopy (1H MRS) at 1.5 T to establish whether there were changes in relative concentrations of N-acetyl aspartate (NAA), choline (Cho) and creatine (CR) metabolites from those found in healthy brains. Spectra were obtained from two different (2 x 2 x 2 cm) volumes of interest in the left and in the right frontal cortex, normal on MRI. All spectra revealed abnormalities compared with normal spectra obtained from age-matched control subjects. Values outside the normal range for at least one of the metabolite ratios were observed in all patients. Cho/Cr was markedly higher and NAA/Cho and NAA/Cr were markedly lower than in the control subjects. At different times six patients regained awareness and the ability to obey commands, and four were re-examined; changes in metabolite ratios were observed, which were different in individual patients. The NAA/Cho ratio reaches statistical significance in discriminating between the patients with a poor outcome (death or prolonged vegetative state) and those who regained awareness; the dividing line appears to be at a value of about 1.6.

Citations

Oct 29, 2009·Neuroradiology·Luaba TshibandaQuentin Noirhomme
Mar 9, 2004·Brain Research. Brain Research Reviews·Amy J Ross, Perminder S Sachdev
Dec 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·M UzanC Kuday
Dec 6, 2012·Critical Care Research and Practice·P GuldenmundS Laureys
Nov 6, 2007·Critical Care : the Official Journal of the Critical Care Forum·Nicolas WeissLouis Puybasset
Jan 29, 2014·Nature Reviews. Neurology·Joseph T GiacinoNicholas D Schiff
Aug 26, 2010·Neurocritical Care·Silvia MarinoNicola De Stefano
Jun 19, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·C MachadoJ Korein
Mar 29, 2001·The Journal of Head Trauma Rehabilitation·W M BrooksC Gasparovic
Apr 9, 2009·Annals of the New York Academy of Sciences·Thomas LescotLouis Puybasset
Mar 29, 2014·Journal of Neurochemistry·Viktoria FischerAlexei V Egorov
Oct 27, 2015·Topics in Magnetic Resonance Imaging : TMRI·Iain CroallAndrew M Blamire
Feb 17, 2000·Journal of Magnetic Resonance Imaging : JMRI·B A HolshouserD B Hinshaw
Sep 19, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthew G StovellKeri Lh Carpenter

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