Localization and characterization of the human ADP-ribosylation factor 5 (ARF5) gene

Genomics
R E McGuireE D Green

Abstract

ADP-ribosylation factor 5 (ARF5) is a member of the ARF gene family. The ARF proteins stimulate the in vitro ADP-ribosyltransferase activity of cholera toxin and appear to play a role in vesicular trafficking in vivo. We have mapped ARF5, one of the six known mammalian ARF genes, to a well-defined yeast artificial chromosome contig on human chromosome 7q31.3. In addition, we have isolated and sequenced an approximately 3.2-kb genomic segment that contains the entire ARF5 coding region, revealing the complete intron-exon structure of the gene. With six coding exons and five introns, the genomic structure of ARF5 is unique among the mammalian ARF genes and provides insight about the evolutionary history of this ancient gene family.

References

Jan 1, 1992·Current Topics in Microbiology and Immunology·I M ServentiM Vaughan
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T StearnsR A Kahn
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L MonacoM Vaughan
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D A BobakM Vaughan
Mar 11, 1986·Nucleic Acids Research·G R Alsip, D A Konkel
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J L Sewell, R A Kahn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Artificial Chromosomes

Artificial chromosomes are genetically engineered chromosomes derived from the DNA of a species. Discover the latest research on artificial chromosomes here.

Allen Institute for Brain Science Network

The Allen Institute for Brain Science Network is a not-for-profit biomedical research organization that provides open access to multiple neuroscience tools and resources. Find the latest research from tjr Allen Institute for Brain Science Network here.