Localization and chemical characterization of the audiogenic stress pathway

Annals of the New York Academy of Sciences
M PalkovitsT B Usdin

Abstract

Neuronal pathways involved in stress responses to extreme somatosensory stimuli were investigated by immunostaining, viral tract tracing, and experimental brain surgery in rats. Acute audiogenic stress, which elicits an immediate marked elevation in plasma ACTH and corticosterone concentrations, was used as a model. Loud noise (105 dB, 30 min) elicited c-fos activation within neurons in all of the components of the auditory system and stress-sensitive brain nuclei, including corticotropin-releasing hormone-synthesizing parvicellular neurons in the hypothalamic paraventricular nucleus (PVN). c-Fos activation was also seen in the medial paralemniscal nucleus in the pons (MPL) and in the subparafascicular nucleus (SPF) in the midbrain. After injection of neurotropic virus (pseudorabies, Bartha strain) into the PVN, neurons in the MPL and the parvicellular portion of the SPF were retrogradely infected. It has been shown by immunostaining that MPL and SPF neurons express a newly discovered neuropeptide, tuberoinfundibular peptide of 39 residues (TIP39). TIP39 is present in a fine neuronal network in the PVN. Audiogenic stress-elicited c-fos activation in TIP39-containing neurons of the MPL and SPF. TIP39 immunoreactivity disappeared...Continue Reading

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Citations

Nov 26, 2009·Brain Structure & Function·Miklós PalkovitsTed B Usdin
Nov 15, 2011·Brain Structure & Function·Tamás VargaArpád Dobolyi
Nov 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jeansok J KimHugh T Blair
Feb 3, 2016·Frontiers in Neuroanatomy·Alexander A NevueChristine V Portfors
Oct 19, 2010·Ultrasonics Sonochemistry·R Vinu, Giridhar Madras
May 23, 2008·Journal of Chemical Neuroanatomy·Dávid BrennerArpád Dobolyi
Sep 5, 2008·The Journal of Comparative Neurology·Tamás VargaArpád Dobolyi
Jan 17, 2012·The Journal of Comparative Neurology·Dana R ZieglerWilliam E Cullinan
Dec 20, 2005·Neuroscience·J WangA Dobolyi
Jun 5, 2012·Biophysical Chemistry·Nazul Jared López Alamilla, Ivan Santamaría Holek
Apr 20, 2016·Annual Review of Physical Chemistry·Baron Peters
Jul 28, 2006·The Journal of Comparative Neurology·Arpád DobolyiTed Björn Usdin
Jun 25, 2005·The Journal of Comparative Neurology·Arpád DobolyiMiklós Palkovits
Jan 21, 2020·Bioscience Trends·David Fernandez-QuezadaFernando Jáuregui Huerta

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