Localization and density of myeloid leucocytes in the periodontal ligament of normal rat molars

Archives of Oral Biology
L KanH Suda

Abstract

The phenotypic distribution and density of macrophage-associated antigen-expressing cells in the periodontal ligament (PDL) of normal rat mandibular first molars was evaluated by immunohistochemistry, and an attempt made to identify dendritic cells (DCs) by immunoelectron microscopy. Cells immunopositive to ED1 (a general macrophage marker) were widely distributed throughout the PDL and were most common around blood vessels. A small number of T lymphocytes and OX62 (anti-veiled cells and gammadelta T cells)-positive DC-like cells were also found. The relative density of cells immunopositive to ED9 (CD14), OX42 (CD11b), OX6 (anti-class II MHC molecules), ED2 (anti-tissue-resident macrophages), 8A2 (CD11c) and WT.1 (CD11a) varied in the mesial, distal and periapical regions of the distal root and the furcal region. This finding suggests that there are several subpopulations of ED1-positive cells which express various combinations of these markers. Immunoelectron microscopy revealed that a small, but distinct, subpopulation of ED1- and OX6-positive cells did have a DC-like ultrastructure, although the majority of these cells were identified as macrophages. The DC-like cells were characterized by poorly developed lysosomal structur...Continue Reading

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Citations

Nov 28, 2007·Cell and Tissue Research·Tomoatsu KanekoHideaki Suda
Apr 7, 2011·Biological & Pharmaceutical Bulletin·Jin ChungHyung Keun Kim
Nov 26, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Osamu TadokoroKatsuhiro Inoue
Apr 21, 2006·Archives of Medical Research·Juan Carlos Hernández-GuerreroConstantino Ledesma-Montes
Mar 31, 2017·Acta Odontologica Scandinavica·Yanfen LiYin Xiao

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