PMID: 9168857Jun 1, 1997Paper

Localization and expression of CSF-1 receptor in rat dental follicle cells

Journal of Dental Research
G E WiseR L Grier

Abstract

Colony-stimulating factor-1 (CSF-1) accelerates tooth eruption in rats and is localized in the dental follicle, a loose connective tissue sac that is necessary for eruption to occur. CSF-1 enhances the cellular events that occur in the follicle prior to eruption--namely, an influx of monocytes into the follicle early post-natally to form the osteoclasts needed to resorb bone for the eruption pathway. Because CSF-1 levels are at a peak at day 3 post-natally, and because CSF-1 has an autocrine effect on its own gene expression, the question remains as to what causes the subsequent decline in CSF-1 protein and mRNA after day 3 post-natally. To determine if the autocrine effect is inhibited through the CSF-1 receptor, analysis of the CSF-1 receptor mRNA levels in cultured dental follicle cells reveals that high concentrations of CSF-1 reduce the gene expression of the CSF-1 receptor. Interleukin 1 alpha, a molecule that enhances CSF-1 gene expression, has no effect on CSF-1 receptor mRNA levels. Immunostaining for the CSF-1 receptor protein shows that it is present in the dental follicle early post-natally and is either absent or greatly reduced by day 10 post-natally. Earlier studies showed that the mRNA levels of the CSF-1 recept...Continue Reading

References

Mar 1, 1992·Cell and Tissue Research·G E WiseW Fan
Jan 1, 1984·Archives of Oral Biology·S C Marks, D R Cahill
Jul 1, 1980·Journal of Oral Pathology·D R Cahill, S C Marks
Sep 1, 1995·Journal of Dental Research·G E WiseL Zhao
Jan 1, 1995·Journal of Dental Research·G E Wise, F Lin
Jan 1, 1994·Journal of Cell Science. Supplement·M F Roussel

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Citations

Apr 17, 2001·Biochemical and Biophysical Research Communications·J C ParkK Y Han
Jan 30, 2003·Health Physics·M M Pujadas BigiA M Ubios
Aug 23, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G E WiseR N D'Souza
Feb 24, 2001·Journal of Dental Research·G E WiseQ Zhang
Oct 2, 2004·European Journal of Oral Sciences·G E WiseS Yao

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