Localization and mobility of glucose-coated gold nanoparticles within the brain

Nanomedicine
Radka GromnicovaDavid K Male

Abstract

To identify the localization of glucose-coated gold nanoparticles within cells of the brain after intravascular infusion which may point to the mechanism by which they cross the blood-brain barrier. Tissue distribution of the nanoparticles was measured by inductively-coupled-mass spectrometry and localization within the brain by histochemistry and electron microscopy. Nanoparticles were identified within neurons and glial cells more than 10 μm from the nearest microvessel within 10 min of intracarotid infusion. Their distribution indicated movement across the endothelial cytosol, and direct transfer between cells of the brain. The rapid movement of this class of nanoparticle (<5 nm) into the brain demonstrates their potential to carry therapeutic biomolecules or imaging reagents.

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Citations

Aug 4, 2019·Progress in Neurobiology·Kasper Bendix JohnsenTorben Moos
Oct 30, 2020·International Journal of Nanomedicine·Shubin WangYuanming Pan
Aug 4, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Syed Mohd Danish RizviGhulam Md Ashraf
Jul 12, 2021·Advanced Drug Delivery Reviews·Amira Sayed HanafyAlf Lamprecht

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Methods Mentioned

BETA
electron microscopy
light microscopy
transmission electron microscopy

Software Mentioned

AmtV

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