Localization and temporal expression of prolactin receptor in human endometrium

The Journal of Clinical Endocrinology and Metabolism
R L JonesA S McNeilly

Abstract

Extrapituitary PRL is synthesized by the decidualized endometrial stromal cells from the mid to late secretory phase in the nonpregnant cycle and throughout pregnancy. The function of PRL in the uterus is unknown, but the temporal expression indicates a role in implantation and placentation. PRL is a powerful immunoregulatory agent, and thus, a role in modulating endometrial leukocytes may be envisaged. To investigate the site of action of PRL, immunohistochemistry was conducted to localize the PRL receptor (PRL-R). In addition, ribonucleic acid was extracted and reverse transcriptase-PCR for PRL-R was conducted. PRL-R protein was immunolocalized to the glandular epithelium and a subset of stromal cells from the mid to late secretory phase of the menstrual cycle and in early decidua. PRL-R transcripts were also detected from the late secretory phase and first trimester decidua. These findings indicate that the receptor is expressed in a temporal pattern similar to that of PRL. PRL-R expression in the glandular epithelium is consistent with a role in regulating glandular activity. Furthermore, immunoreactivity for PRL-R in a subset of stromal cells may be evidence for paracrine interactions between decidualized cells or an immun...Continue Reading

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Citations

Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Zack PapperDerek E Wildman
Sep 28, 2012·Journal of Endocrinological Investigation·M GaldieroA Colao
Oct 10, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Vinícius Cestari do AmaralEdmund Chada Baracat
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Apr 4, 2014·Molecular Endocrinology·Robert J Marano, Nira Ben-Jonathan
Aug 8, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mariana PaulsonAngelica Lindén Hirschberg
Oct 6, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Jin Ju KimMin A Hong
Oct 1, 2005·Endocrinology·Eric R HugoNira Ben-Jonathan
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Feb 23, 2020·Journal of the Endocrine Society·Munekage YamaguchiHidetaka Katabuchi
Sep 1, 2012·Journal of Endocrinological Investigation·M GaldieroA Colao
Jan 23, 2021·Journal of Clinical Medicine·Hiromi MurataHidetaka Okada
May 8, 2021·Frontiers in Cell and Developmental Biology·Ruben HeremansHugo Vankelecom
Jun 16, 2010·Frontiers in Neuroendocrinology·Alison J Douglas

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