PMID: 15225128Jul 1, 2004Paper

Localization, expression and control of adrenocorticotropic hormone in the nucleus preopticus and pituitary gland of common carp (Cyprinus carpio L.)

The Journal of Endocrinology
Juriaan R MetzGert Flik

Abstract

Adrenocorticotropic hormone (ACTH) takes a central role in the hypothalamo-pituitary-interrenal axis (HPI axis), which is activated during stress. ACTH is produced by the corticotrope cells of the pituitary pars distalis (PD) and is under control of factors from the nucleus preopticus (NPO). The distribution of ACTH in the hypothalamo-pituitary system in common carp (Cyprinus carpio L.) was assessed by immunohistochemistry. ACTH and beta-endorphin immunoreactivity was observed in the ACTH cells in the PD and in the NPO. Nerve fibers, originating from the NPO and projecting to the pituitary gland, contain beta-endorphin, but not ACTH, and these fibers either control the pituitary pars intermedia (PI) through beta-endorphin or release it to the blood. The release of pituitary ACTH (studied in a superfusion setup) must in vivo be under predominant inhibitory control of dopamine. Release of ACTH is stimulated by corticotropin-releasing hormone, but only when ACTH cells experience dopaminergic inhibition. The expression of the precursor pro-opiomelanocortin in (POMC) NPO, PD and PI was studied in an acute restraint stress paradigm by real-time quantitative polymerase chain reaction (RQ-PCR). POMC gene expression is upregulated in th...Continue Reading

Citations

Oct 22, 2008·The Journal of Endocrinology·Edwin J W GevenPeter H M Klaren
Feb 14, 2016·General and Comparative Endocrinology·Yugo WatanabeBert De Groef
May 1, 2012·General and Comparative Endocrinology·Marnix GorissenGert Flik
May 12, 2012·General and Comparative Endocrinology·Mauro VallarinoRobert M Dores
May 17, 2011·Journal of Neuroscience Methods·Hanna Kalamarz-KubiakEwa Kulczykowska
Jul 16, 2015·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Hanna Kalamarz-KubiakEwa Kulczykowska
Nov 4, 2008·Brain, Behavior, and Immunity·Magdalena ChadzinskaB M Lidy Verburg-van Kemenade
Aug 16, 2014·Fish & Shellfish Immunology·Gino NardocciRicardo Fernández
Jul 2, 2016·The Science of the Total Environment·Kathrin WardWilfried Endlicher
Jan 13, 2006·General and Comparative Endocrinology·Gert FlikMark O Huising
May 5, 2017·Cancer Informatics·Liansheng Larry TangLeighton Chan
Sep 20, 2007·The Journal of Comparative Neurology·Paul M Forlano, Roger D Cone
May 14, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Juriaan R MetzGert Flik
Oct 13, 2020·General and Comparative Endocrinology·Karine RousseauSylvie Dufour

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