Abstract
Conventional surfactant proteins (A, B, C, and D) are important players of the innate immunity in the central nervous system and serve as effective regulators of cerebrospinal fluid rheology, probably being involved in clearance of detrimental metabolites like beta-amyloid and phospho-tau. Recently, a novel surfactant protein, SP-G, was described in kidneys and peripheral endocrine and exocrine glands. So far, its presence and possible functions in the central nervous system are unknown. Therefore, our study aimed to elucidate the presence of SP-G in the brain and its concentration in normal and pathologic samples of cerebrospinal fluid in order to gain first insight into its regulation and possible functions. A total of 121 samples of human cerebrospinal fluid (30 controls, 60 hydrocephalus patients, 7 central nervous system infections, and 24 brain hemorrhage patients) and 21 rat brains were included in our study. CSF samples were quantified using a commercially available ELISA system. Results were analyzed statistically using SPSS 22, performing Spearman Rho correlation and ANOVA with Dunnett's post hoc analysis. Rat brains were investigated via immunofluorescence to determine SP-G presence and colocalization with common mar...Continue Reading
References
Jan 1, 1978·Journal of the Neurological Sciences·C M JacqueN A Baumann
Oct 27, 1980·Brain Research·U RoessmannP Gambetti
Dec 14, 2004·Molecular Immunology·Hitomi Sano, Yoshio Kuroki
Jun 3, 2008·Biochimica Et Biophysica Acta·Jesús Pérez-Gil
Jun 10, 2010·Innate Immunity·Nades Palaniyar
Jun 16, 2012·Frontiers in Immunology·Annapurna NayakUday Kishore
Jul 7, 2012·PloS One·Rashmi A MittalAndreas Holzinger
Oct 25, 2012·PloS One·Felix RauschWolfgang Brandt
Feb 26, 2013·The Journal of Clinical Investigation·Jeffrey J IliffHelene Benveniste
Oct 8, 2013·PloS One·Stefan SchobLars Bräuer
May 10, 2015·Der Radiologe·J M LiebF J Ahlhelm
Mar 16, 2016·Acta Neuropathologica·Alan W J MorrisRoxana O Carare
Mar 20, 2016·Cellular and Molecular Neurobiology·Erik N T P BakkerRoxana O Carare
Apr 8, 2016·Current Opinion in Hematology·Panida LertkiatmongkolPeter J Newman
Jul 1, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Stefan SchobEckhard Fiedler
Sep 23, 2016·PloS One·Stefan SchobMatthias Preuß
Nov 14, 2016·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Stefan SchobMatthias Preuß
Dec 29, 2017·Molecular Neurobiology·Stefan SchobUlf Quäschling