Localization of 11beta-hydroxysteroid dehydrogenase type 2 in rat tissues: in situ studies

Endocrinology
B L Roland, J W Funder

Abstract

In the rat, the enzyme 11beta-hydroxysteroid dehydrogenase 2 (11betaHSD2) converts the glucocorticoid corticosterone into receptor-inactive 11-dehydrocorticosterone, thereby allowing preferential access of aldosterone to mineralocorticoid receptors (MR). The present study examines the distribution of this enzyme by in situ hybridization, using a homologous complementary RNA probe for 11betaHSD2. 11betaHSD2 messenger RNA was detected in classic epithelial aldosterone target tissues (kidney, salivary glands, and colon), the female reproductive system (ovary, oviduct, uterus, and placenta), and the adrenals; levels in heart, testis, and liver were below the limits of detection. We interpret the finding of 11betaHSD2 expression in both classical MR-containing aldosterone target tissues and a variety of other tissue as evidence that in the rat, the enzyme may play physiological roles in addition to that of excluding glucocorticoids from epithelial MR.

Citations

May 19, 2011·Clinical and Experimental Pharmacology & Physiology·Kenji OkiCelso E Gomez-Sanchez
Nov 28, 2007·Endocrinology·Elise P Gomez-SanchezCelso E Gomez-Sanchez
Mar 4, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Elise P Gomez-SanchezCelso E Gomez-Sanchez
Sep 2, 1998·Molecular and Cellular Endocrinology·F ArcuriM Cintorino
Sep 24, 2004·Canadian Journal of Physiology and Pharmacology·Marisa ZallocchiMaría C Damasco
May 17, 2001·Current Hypertension Reports·C E Gomez-Sanchez, E P Gomez-Sanchez
Mar 29, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·P KonstantakouG Valsamakis
Aug 10, 2006·American Journal of Physiology. Renal Physiology·Anikó Náray-Fejes-Tóth, Géza Fejes-Tóth
Aug 1, 2013·Physiological Reviews·Karen ChapmanJonathan Seckl
Apr 5, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Joanne BlairRichard Ross
Dec 13, 2016·Heart Failure Reviews·Milla Marques HermidorffMauro César Isoldi
Apr 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Elise P Gomez-SanchezCelso E Gomez-Sanchez
Mar 30, 2007·Clinical Science·Morag J YoungAmanda J Rickard
Oct 20, 2009·Experimental Physiology·Elise P Gomez-SanchezCelso E Gomez-Sanchez
Feb 7, 2021·General and Comparative Endocrinology·Michelle A Rensel, Barney A Schlinger
Feb 20, 2021·Molecular and Cellular Endocrinology·Elise P Gomez-Sanchez, Celso E Gomez-Sanchez
Jan 10, 2002·The American Journal of the Medical Sciences·P C White
Dec 15, 2010·Frontiers in Neuroendocrinology·Caitlin S WyrwollJonathan R Seckl

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