Localization of adiponectin and its receptor and its possible roles in the ovary of a vespertilionid bat, Scotophilus heathi

General and Comparative Endocrinology
Ajit Singh, Amitabh Krishna

Abstract

The aim of this study was to evaluate the seasonal variation in serum adiponectin levels and ovarian expression of adiponectin and its receptor in the Scotophilus heathi bat and their relationship to the changes in the body fat mass, serum insulin and luteinizing hormone (LH) levels, and ovarian activity. A very high level of circulating adiponectin was found during recrudescence, whereas a very low level of circulating adiponectin was observed during pre-ovulatory period. The increased circulating adiponectin level coincided with fat deposition, insulin resistance and hyperinsulinemia (HI) in S. heathi. Immunocytochemical study in the ovary of bat showed localization of adiponectin mainly in thecal-interstitial cells (TICs), and adiponectin receptor 1 (AdipoR1) in the granulosa cells of growing follicles, but showed no staining in atretic follicle. Seasonal changes in ovarian adiponectin and AdipoR1 levels showed two peaks (during recrudescence and ovulatory phases) coinciding with two periods of follicular development. Adiponectin in the absence of LH, as occur during recrudescence, stimulates androstenedione (A4) synthesis in vitro by up-regulating the insulin receptor (IR). Adiponectin in presence of LH, as occur during pre...Continue Reading

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Citations

May 3, 2014·International Journal of Endocrinology·Anna MaleszkaTadeusz Kaminski
Oct 12, 2014·Molecular and Cellular Endocrinology·Ajit SinghAmitabh Krishna
Sep 23, 2014·General and Comparative Endocrinology·Ajit SinghAmitabh Krishna
Jul 17, 2012·General and Comparative Endocrinology·Ajit Singh, Amitabh Krishna
May 3, 2014·The Journal of Steroid Biochemistry and Molecular Biology· Anuradha, Amitabh Krishna
Sep 16, 2017·Reproduction, Fertility, and Development·Anusha SinghAmitabh Krishna
Oct 9, 2014·Molecular Reproduction and Development· Anuradha, Amitabh Krishna
Apr 20, 2018·Reproductive Sciences·Anusha SinghAmitabh Krishna

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