Localization of alpha/beta and gamma/delta T lymphocytes in Cryptosporidium parvum-infected tissues in naive and immune calves.

Infection and Immunity
M S AbrahamsenM A Jutila

Abstract

The nature of the host's T-lymphocyte population within the intestinal villi following Cryptosporidium parvum infection was characterized with a bovine model of cryptosporidiosis. In naive animals, infection with C. parvum resulted in substantial increases in the numbers of alpha/beta T cells, both CD4+ (150%) and CD8+ (60%), and of gamma/delta T cells (70%) present within the intestinal villi of the infected ileum. In immune animals, the host T-lymphocyte response to a challenge infection with C. parvum was restricted to alpha/beta T cells. The number of CD4+ T cells within the Peyer's patch of the ileum increased dramatically; however, there was little change in the number or localization of CD4+ T cells within the intestinal villi. In contrast, the number of CD8+ T cells within the intestinal villi increased following a challenge infection. In addition, the CD8+ T cells were found to be intimately associated with the epithelial cells of the intestinal villi. The precise correlation between the accumulation of CD8+ T cells and the normal site of parasite development suggests an important role for CD8+ T cells in the immune animal.

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Citations

Dec 21, 2000·Parasite Immunology·V McDonald
Nov 15, 2001·Animal Health Research Reviews·C R Wyatt
Oct 18, 2006·Parasite Immunology·T Evering, L M Weiss
Sep 19, 2007·The Korean Journal of Parasitology·Sang-Mee Guk, Jong-Yil Chai
Oct 28, 2011·Expert Review of Anti-infective Therapy·Vincent McDonald
Jul 30, 2003·Animal Health Research Reviews·James A Harp
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jodi F HedgesMark A Jutila
May 24, 2008·The Journal of Infectious Diseases·Cirle Alcantara WarrenRichard L Guerrant
Aug 13, 2017·Veterinary Research·Sarah ThomsonElisabeth A Innes
Oct 25, 2000·Veterinary Immunology and Immunopathology·C R WyattL E Perryman
Sep 2, 1998·International Journal for Parasitology·M S Abrahamsen
Nov 27, 1999·International Journal for Parasitology·D C de GraafJ E Peeters
Nov 27, 1999·International Journal for Parasitology·D C de GraafA Bonnin
Aug 23, 2002·Microbes and Infection·Michael W Riggs

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