PMID: 9166116May 1, 1997Paper

Localization of angiotensin II receptor subtypes AT1 and AT2 in the pancreas of rodents

The Journal of Endocrinology
P S LeungP Y Wong

Abstract

Previous studies have demonstrated the existence of several key components of the renin-angiotensin system in the pancreas. In the present study, the localization of angiotensin II receptor subtypes, type I (AT1) and type II (AT2), in the mouse and the rat pancreas was studied by immunocytochemistry using specific antipeptide antibodies against the second extracellular loops of AT1 and AT2 receptors in conjunction with confocal laser scanning microscopy. In the mouse, immunoreactivity for AT1 and AT2 was observed predominantly in the endothelia of the blood vessels and the epithelia of the pancreatic ductal system. Similar distribution of immunoreactivity for AT1 and AT2 was also observed. However, the intensity of immunoreactivity for AT1 and AT2 was stronger in the rat than that found in the mouse pancreas. Much weaker immunostaining for both AT1 and AT2, as compared with that found in ductal regions, was also found in the acini of the rodent pancreas. Together with the previous findings, the present results suggest that AT1 and/or AT2 receptors may play a role in regulating pancreatic functions in the rodent.

Citations

Sep 21, 2000·Molecular and Cellular Endocrinology·P S LeungR Nobiling
Nov 6, 2001·Molecular and Cellular Endocrinology·P S LeungT K Lau
Mar 15, 2000·Molecular and Cellular Endocrinology·W P ChanP S Leung
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Po Sing Leung, Mark C Chappell
Jun 8, 2011·Antioxidants & Redox Signaling·Yuk Cheung Chan, Po Sing Leung
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Jan 10, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Kelly PutnamLisa A Cassis
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Jan 16, 2007·The Journal of Physiology·Po Sing Leung
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