PMID: 19912897Dec 1, 1992Paper

Localization of beta-endorphin in rabbit pancreatic islets

Molecular and Cellular Neurosciences
M ZhangR L Schleicher

Abstract

To determine whether beta-endorphin might play a physiological role in regulating insulin secretion, we examined the rabbit pancreas for an endogenous source of beta-endorphin. Specific antibodies to beta-endorphin were used together with anti-insulin, anti-glucagon, and anti-somatostatin in single-labeled and double-labeled indirect immunofluorescence and in sequential avidin-biotin-peroxidase immunohistochemistry. Light microscopic examination of rabbit islets revealed beta-endorphin immunoreactivity primarily in the beta cells. Approximately 97% of the cells exhibiting beta-endorphin immunoreactivity contained immunoreactive insulin; whereas many, but not all, of the insulin-containing cells contained immunoreactive beta-endorphin. Strongly beta-endorphin-positive cells were usually weakly insulin-positive; and strongly insulin-positive cells were often beta-endorphin-negative. The beta-endorphin-positive cells that were insulin-negative were identified as immunoreactive glucagon- or somatostatin-containing cells. The intensity of the immunoreactive beta-endorphin appeared to be more heterogeneous than the staining intensities of other hormones. Together with the previously reported data on the effects of beta-endorphin on p...Continue Reading

References

Dec 28, 1978·Histochemistry·D GrubeE Weber
Oct 1, 1979·The Journal of Clinical Endocrinology and Metabolism·J F BruniS S Yen
Jan 1, 1989·Pancreas·A M PowellL Recant
Jan 1, 1989·Acta histochemica·H H von DorscheH Zühlke
Dec 3, 1987·The New England Journal of Medicine·D G BostwickK G Bensch
Aug 1, 1986·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J Knudtzon
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B WiedenmannV E Gould
Aug 1, 1985·Immunological Investigations·A PolsonK J van der Merwe
Jan 1, 1984·Diabetes Care·D Giugliano

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Citations

Oct 31, 1994·Annals of the New York Academy of Sciences·A J KastinJ E Zadina
May 19, 2011·Biochemistry. Biokhimii︠a︡·Yu A Kovalitskaya, E V Navolotskaya
Dec 19, 2008·European Journal of Gastroenterology & Hepatology·Hye Young SungIn-Sik Chung

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