PMID: 16862320Jul 25, 2006Paper

Localization of Brugia malayi (sub-periodic) adults in different organs of Mastomys coucha and its influence on microfilaraemia and host antibody response

Memórias do Instituto Oswaldo Cruz
K Athisaya MaryK P Paily

Abstract

Lymphatic filariasis caused by nematode parasites Wuchereria bancrofti or Brugia malayi is a spectral disease and produces wide range of immune responses and varying levels of microfilaraemia in infected individuals. The relationship between the immune response of host and the developmental stage of the parasite as well as the microfilariae (mf) density and specific location of the adult worms is yet to be understood. As an experimental model, B. malayi adapted in the experimental animal Mastomys coucha has been used widely for various studies in filariasis. The present study was to assess microfilaraemia as well as the humoral immune response of M. coucha during various stages of B. malayi development and their localization in different organs. The result showed that the density of mf in the circulating blood of the experimental animal depended upon the number of female worms as well as the location and co-existence of male and female worms. The mf density in the blood increased with the increase in the number of females. The clearance of inoculated infective stage (L3) or single sex infection or segregation of male and female to different organs of infected host resulted in a microfilaraemic condition. With respect to antibod...Continue Reading

References

Mar 1, 1991·Immunology Today·C L King, T B Nutman
May 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·G DreyerD Addiss
Dec 1, 1997·Indian Journal of Clinical Biochemistry : IJCB·U R Rao, T R Klei

Citations

Dec 1, 2009·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·K P PailyP K Das
Aug 28, 2007·Lab Animal·Abdul Mabood KhanJagdish Mahanta
Jul 5, 2013·Clinical Microbiology Reviews·C Paul MorrisEdward Mitre
Mar 31, 2018·PLoS Neglected Tropical Diseases·Belinda M Jackson-ThompsonEdward Mitre
Apr 4, 2020·PLoS Neglected Tropical Diseases·Canhui LiuThomas R Unnasch

Related Concepts

Helminth Antibodies
Enzyme-Linked Immunosorbent Assay
Filariasis
Host-Parasite Interactions
Microfilaria
Muridae
Sex Ratio
Brugia malayi
Parasitemia

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.