Localization of candidate genomic regions influencing paradoxical sleep in mice

Neuroreport
Mehdi TaftiJ L Valatx

Abstract

Quantitative trait loci (QTL) approach was used in CXB recombinant inbred mice for preliminary identification of candidate regions on the mouse genome that influence sleep. The only provisional QTLs identified were associated with paradoxical sleep (PS). PS during the light period was associated with markers on chromosome 7 between 7 and 20 centimorgan from the centromere. For PS during the dark period, a single QTL was identified on chromosome 5, near the Clock gene. The 24 h amount of PS was influenced by markers on chromosomes 2, 17, and 19. This first QTL mapping study strongly suggests that a complex behaviour like PS can be controlled by only a few genes.

References

Jan 1, 1978·Progress in Brain Research·J L Valatx
Sep 1, 1992·Physiology & Behavior·J M NeiderhiserG E McClearn
Feb 1, 1974·Physiology & Behavior·J K Friedmann
Mar 1, 1974·Brain : a Journal of Neurology·J R HeronB A Milner
Jul 28, 1972·Nature·J L ValatxM Jouvet
Sep 30, 1994·Science·E S Lander, N J Schork
Jun 17, 1994·Science·J C CrabbeK J Buck

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Citations

Dec 18, 2002·Journal of Neurobiology·Paul J Shaw, Paul Franken
Mar 2, 2005·Sleep Medicine Reviews·Y DauvilliersMehdi Tafti
Oct 20, 2000·Brain Research. Molecular Brain Research·P J ShiromaniM E Charness
Jul 19, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·X TanI Feinberg
Jun 18, 2003·Respiratory Physiology & Neurobiology·Kingman P Strohl
Jun 18, 2003·Respiratory Physiology & Neurobiology·Miroslaw Mackiewicz, Allan I Pack
Jul 2, 1999·Journal of Sleep Research·U Schibler, M Tafti
Jul 2, 1999·Journal of Sleep Research·P Linkowski
Jul 2, 1999·Journal of Sleep Research·M TaftiP Franken
Jul 2, 1999·Journal of Sleep Research·J L ValatxD Bucchini
Nov 6, 2008·Annual Review of Genetics·Rozi AndreticMehdi Tafti
Jul 27, 2001·Current Biology : CB·U Albrecht
Apr 17, 2013·Physiological Reviews·Björn Rasch, Jan Born
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L A Toth, M R Opp
Feb 14, 2002·Journal of Applied Physiology·Mehdi Tafti, Paul Franken
Oct 2, 1998·The American Journal of Physiology·P FrankenM Tafti

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