Localization of CD44, the hyaluronate receptor, on the plasma membrane of osteocytes and osteoclasts in rat tibiae

Cell and Tissue Research
H NakamuraH Ozawa

Abstract

CD44 is a multifunctional adhesion molecule that binds to hyaluronic acid, type I collagen, and fibronectin. We have studied the immunohistochemical localization of CD44 in bone cells by confocal laser scanning microscopy and transmission electron microscopy in order to clarify its role in the cell-cell and/or cell-matrix interaction of bone cells. In round osteoblasts attached to bone surfaces, immunoreactivity is restricted to their cytoplasmic processes. On the other hand, osteocytes in bone matrices show intense immunoreactivity on their plasma membrane. Intense immunoreactivity for CD44 can be detected on the basolateral plasma membranes of osteoclasts. There is considerably less reactivity observed in the area of the plasma membrane that is in direct contact with bone. The pre-embedding electron-microscopical method has revealed that CD44 is mainly localized on the basolateral plasma membrane of osteoclasts. However, the ruffled border and clear zone show little immunoreactivity. A CD44-positive reaction can be detected on both plasma membranes in the contact region between osteoclasts and osteocytes. These findings suggest that: 1) cells of the osteoblast lineage express CD44 in accordance with their morphological change...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G R ScreatonJ I Bell
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·F P ReinholtD Heinegård
Feb 1, 1992·The Journal of Cell Biology·S Jalkanen, M Jalkanen
Mar 8, 1991·Cell·E Ruoslahti, Y Yamaguchi
Jul 1, 1990·The Journal of Experimental Medicine·K MiyakeP W Kincade
Feb 1, 1990·The Journal of Experimental Medicine·K MiyakeP W Kincade
Sep 1, 1987·The Journal of Cell Biology·B E Lacy, C B Underhill
Nov 1, 1988·Endocrinology·N TakahashiT Suda
Feb 1, 1988·The Journal of Cell Biology·E L Kalomiris, L Y Bourguignon
Nov 1, 1984·The Journal of Cell Biology·K JacobsonJ T August
Jan 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D E HughesR Simpson
Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H Nakamura, H Ozawa

❮ Previous
Next ❯

Citations

Aug 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H Nakamura, H Ozawa
Nov 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H Nakamura, H Ozawa
Sep 18, 2013·Calcified Tissue International·Mitchell B SchafflerOran Kennedy
Apr 1, 1996·Bone·E M AardenM H Helfrich
Sep 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yilin WangSheldon Weinbaum
Mar 27, 2010·The Journal of Veterinary Medical Science·Kosei NakajimaKen-ichiro Mutoh
Dec 28, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jay J CaoBernard P Halloran
Jan 8, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y KatoL F Bonewald
Aug 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J R KaniaS R Kupfer
Jan 27, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T SatoJ M Delaissé
Aug 24, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K StewartJ N Beresford
Aug 7, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K SuzukiJ Sodek
Feb 13, 2001·International Journal of Experimental Pathology·A Vignery
Jan 17, 2003·Molecular Biology of the Cell·M A ChellaiahK A Hruska
Dec 20, 2002·Connective Tissue Research·Jaro SodekMaurice Ringuette
Jul 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K J NoonanR J Midura
Jul 25, 2003·Microscopy Research and Technique·Jean-Marie DelaisséLaurence Blavier
Oct 20, 2006·Acta histochemica·Rosalia LeonardiCandida Caltabiano
Dec 4, 2004·Journal of Cellular Biochemistry·Teun J de VriesVincent Everts
May 28, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Li-Dan YouMitchell B Schaffler
Sep 16, 2009·Annals of the New York Academy of Sciences·L Díaz-RodríguezC Ruiz
Dec 1, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ahnders FranzénDick Heinegård
Apr 25, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dominic Falconi, Jane E Aubin
May 5, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Akiko SuzukiTakeyasu Maeda
Jul 26, 2006·Experimental Hematology·Ingrid G Winkler, Jean-Pierre Lévesque
Jun 17, 2006·Bioscience Reports·O García-MartínezC Ruiz
Jul 21, 2000·Biochimica Et Biophysica Acta·I OhizumiT Mayumi
Sep 3, 2016·Experimental & Molecular Medicine·Gregory R SondagFayez F Safadi
Feb 7, 2009·Tissue Engineering. Part a·Marc-Olivier MontjoventDominique P Pioletti
Apr 4, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A L TuhkanenR Tammi
Oct 6, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·J SodekM D McKee
Aug 26, 1998·The British Journal of Surgery·K HeelJ Hall
Nov 7, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J W StevensJ A Maynard
Jul 2, 2014·Journal of Materials Science. Materials in Medicine·Bérengère J C LuthringerRegine Willumeit
Jul 30, 2021·Biological Chemistry·Juliane Salbach-HirschLorenz C Hofbauer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
D E HughesR Simpson
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
H Nakamura, H Ozawa
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
K J NoonanR J Midura
© 2021 Meta ULC. All rights reserved